Background Takayasu arteritis (TAK) is a chronic, large-vessel arteritis predominantly affecting aorta, its major branches and the pulmonary arteries. Vitamin D, as a steroidal hormone, has recently been shown to have immunoregulatory and immunosuppressive effects. Low vitamin D levels are demonstrated in various autoimmune disorders.
Objectives The association between Vitamin D deficiency and non-specific musculoskeletal pain, including fibromyalgia (FM) syndrome, is also controversial. The aim of this study is to investigate vitamin D levels in patients with TAK and to investigate the association between fibromyalgia and vitamin D deficiency in this group.
Methods The study included 36 patients with TAK and 30 age and sex-matched healthy control subjects. Plasma 25-hydroxy vit D [25(OH) vit D] levels were measured with HPLC. “Deficiency” was defined as 25(OH) vit D level below 25 nmol/ liter and “insufficiency” as below 50 nmol/liter. All patients were examined for FM tender points and asked to complete new ACR 2010 FM questionnaire for FM.
Results Plasma 25(OH) vitamin D were significantly lower in TAK patients (16.93±10.62 nmol/liter) than healthy controls (64.63±21.82 nmol/liter). The frequency of vitamin D deficiency was 83.3% in patients with TAK compared to 3.3% in controls. Plasma 25(OH) vit D levels were similar between clinically active and inactive patients. No association was also observed between vitamin D levels and the presence of FM (p=0.263 for 1990 Criteria, p=0.789 for ACR-2010 Criteria).
Conclusions We observed a high prevalence of Vitamin D deficiency in patients with TAK, however without any association with the presence of FM. Vitamin D deficiency can be a predisposing factor for immune activation and we suggest monitorization and replacement of Vitamin D status in all TAK patients.
Disclosure of Interest None Declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.