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AB0443 A minute inquiry of the complete blood count in patients with clinically active behcet’s disease
  1. B. Bitik1,
  2. Y. Ugur2,
  3. A. Tufan1,
  4. R. Mercan1,
  5. M. E. Tezcan3,
  6. S. Haznedaroglu1,
  7. B. Goker1
  1. 1Rheumatology
  2. 2GAZI UNIVERSITY SCHOOL OF MEDICINE, ankara
  3. 3Rheumatology, Dr. Lutfi Kırdar Egitim Arastırma Hastanesi, İstanbul, Turkey

Abstract

Background Behçet’s disease (BD) is a recurrent multisystemic vasculitis with an unknown etiology. It is postulated that endothelium dysfunction may have a knock-on effect on the coming up pathogenesis. The prominent histopathological feature in BD is perivascular infltration of neutrophils, lymphocytes and monocytes. Platelets also play an active role in the inflammatory process particularly in thrombotic events of BD. Neutrophil/lymphocyte ratio (NLR) is one of the new markers of systemic inflammation which is calculated as the ratio of neutrophil count to lymphocyte count. Mean platelet volume (MPV) reflects the platelet function. The complete blood count(CBC) is a simple, easy to obtain test used in almost all patients in clinical practice.

Objectives The aim of this study was to investigate the utility of MPV and NLR as a simple predictor for clinical disease activity in BD.

Methods Retrospective chart review of 104 patients with BD (55 male, 49 female, mean age: 36.4 +/- 8.6 years) and 77 healthy controls (45 male, 32 female, mean age: 36.4 +/- 8.6 years) were done. Clinical data, neutrophil, lymphocyte and platelet counts and MPVs were recorded.

Results 61 of 104 patients with BD were in the active period. 14 patients had vascular involvement (one of the pulmonary, deep venous trombosis or arterial involvements), 14 had neuro Behcet, 29 had uveitis, 5 had pulmonary involvement, and 50 had mucocutaneous involvement. The serum NLR of active patients were significantly higher than those of inactive BD and controls (P < 0.001).

Conclusions Our results indicate that NLR are elevated in patients with active BD, suggesting that CBC may serve as a reliable marker for disease activity of BD.

  1. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, Meghani M, Akhtar M, Costantino T. Expert Rev Cardiovasc Ther. 2013 Jan;11(1):55-9. doi: 10.1586/erc.12.159. PMID:23259445[PubMed - in process]

  2. New insights into the pathogenesis of Behçet’s disease. Pineton de Chambrun M, Wechsler B, Geri G, Cacoub P, Saadoun D. Autoimmun Rev. 2012 Aug;11(10):687-98. doi: 10.1016/j.autrev.2011.11.026. Epub 2011 Dec 11. Review. PMID:22197900[PubMed - indexed for MEDLINE]

Disclosure of Interest None Declared

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