Article Text

AB0432 Overlapping neuropsychiatric manifestations in patients with systemic lupus erythematosus
  1. S. V. Monov1,
  2. R. K. Rashkov1
  1. 1Rheumatology, Medical University, Sofia, Bulgaria


Background Systemic lupus erythematosus (SLE) is a systemic disease of the connective tissue that is characterized bydamages of all organs and systems. Lesions of the nervous system in relation to the underlying disease vary widely depending on the methods used for their detection. In 1999 the ACRAdHocCommitteeofNeuropsychiatricLupusNomenclaturehas defined19possible damagestothe nervous system in SLE patients (pts).

Objectives To identifythe most common variants of overlapping neuropsychiatric manifestations in pts with SLE.

Methods 162 pts with SLE were monitored and assessed. Depending on the characteristics of the clinical course of SLE the pts were divided intotwo groups. Group I included 104 pts with clinically manifested disorders of the nervous system, while Group IIincluded 58ptswith incomplete SLE. In both groups multiple methods for diagnosis and detection of neuropsychiatricdamages were used.

Results Overlapping neuropsychiatric manifestations were observed in 93 (89.42%) pts with clinically manifested damages to the nervous system and in 24 pts (41.38%) with incomplete SLE. In both groups cognitive and autonomous disorders mostly overlapped the other neuropsychiatric manifestations.

Conclusions The types ofoverlapping neuropsychiatric manifestations in pts with SLE and incompleteSLE are various. Studying the overlap of these manifestations in SLE pts may help for optimizing the therapeutic strategies.

Disclosure of Interest None Declared

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