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AB0401 Carotid intimae-media thickness in mexican patients with systemic erythematosus lupus.
  1. I. J. Colunga-Pedraza1,
  2. D. A. Galarza-Delgado1,
  3. F. Góngora-Rivera2,
  4. D. Vega-Morales1,
  5. M. A. Garza-Elizondo1
  1. 1Rheumatology, Hospital Universitario, Monterrey, N.L.
  2. 2Neurology, Hospital Universitario, Monterrey, N.L., Mexico

Abstract

Background The carotid intima-media thickness (CIMT) nowadays is an early marker of atherosclerosis. A CIMT above 75th percentile of a reference population is considered abnormal, and indicates sub clinical atherosclerosis. In patients with SLE, there has been accelerated atherosclerosis, being the leading cause of morbi-mortality in this population.

Objectives To assess the clinical and epidemiological profile of SLE patients with thickening of the CIM.

Methods Descriptive, observational study. Carotid Doppler ultrasound, was performed, obtaining the value of the CIM, with a line equivalent to 200 points. Descriptive analysis was performed for demographic and clinical variables, including measures of central tendency and dispersion. To contrast binomial variables, chi square or Fisher’s exact test, with 2x2 contingency tables; for nonparametric variables, Mann Whitney test was performed; taking as significant, P ≤ 0.05.

Results 69 patients with SLE. Demographics: 95.7% (n = 66) women. Mean age: 30 years, hypertension in 2 subjects and Diabetes Mellitus type 2, in one subject. Post-menopause: 5 patients. Framingham Scale: mean 1.63 ± 1.48. Mean of BMI 25.96 ± 5.93 kg/m2. We obtained the mean carotid intima-media thickness of both lines of 200 points, equivalent to the average of 400 measurements. Then we compared it versus an historical cohort of the same age and gender, and then, we obtained the 75th percentile of the CIMT; the values above the 75th percentile were reported as thickening. We obtained such as 75th percentile: 0571, in people without SLE. 14 patients with SLE exceeded this value, so it is classified with carotid thickening. Later, we compared the main characteristics of the SLE patients with and without carotid thickening, finding statistical significance for: total cholesterol, LDL, menopause and time of use of corticosteroids. We did not found difference between the time of evolutions, age, gender, SLEDAI, autoantibodies.

Conclusions We did not found difference in the traditional cardiovascular risk factors, neither with activity of SLE.

Disclosure of Interest None Declared

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