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OP0110 Treat-To-Target Recommendations for Spondyloarthritis, Including Ankylosing Spondylitis and Psoriatic Arthritis: A Consensus of an International Task Force
  1. J. S. Smolen1,
  2. J. Braun2,
  3. M. Dougados3,
  4. P. Emery4,
  5. O. FitzGerald5,
  6. P. Helliwell4,
  7. A. Kavanaugh6,
  8. T. K. Kvien7,
  9. R. Landewé8,
  10. T. Luger9,
  11. P. Mease10,
  12. I. Olivieri11,
  13. J. Reveille12,
  14. C. Ritchlin13,
  15. M. Rudwaleit14,
  16. M. Schoels15,
  17. J. Sieper16,
  18. M. de Wit17,
  19. D. van der Heijde18
  1. 1Medical University of Vienna and Hietzing Hospital, Vienna, Austria
  2. 2Heerlen, Heerlen, Germany
  3. 3Cochin Hospital, Paris, France
  4. 4Royal Infirmary, Leeds, United Kingdom
  5. 5St. Vincent University Hospital, Dublin, Ireland
  6. 6UCSD Medical School, San Diego, United States
  7. 7Diakonhjemmet Hospital, Oslo, Norway
  8. 8AMC, Amsterdam, Netherlands
  9. 9University of Munster, Munster, Germany
  10. 10Swedish Hospital, Seattle, United States
  11. 11San Carlo Hospital, Potenza, Italy
  12. 12University of Texas, Houston
  13. 13University of Rochester, Rochester, United States
  14. 14Endokrinologikum, Berlin, Germany
  15. 15Hietzing Hospital, Vienna, Austria
  16. 16Charite, Berlin, Germany
  17. 17EULAR-Pare, Zurich, Switzerland
  18. 18Leiden University Medical School, Leiden, Netherlands

Abstract

Background Therapeutic targets have been defined for diseases like diabetes, hypertension or rheumatoid arthritis and adhering to them has improved outcomes. Such recommendations are unavailable for spondyloarthritis.

Objectives To define the treatment target for spondyloarthritis including ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and develop recommendations for achieving the target, including a treat-to-target management strategy.

Methods Based on results of a systematic literature review (performed by MS) and expert opinion, a task force of expert physicians and patients developed recommendations, which were broadly discussed and voted upon in a Delphi-like process. Level of evidence, grade of recommendation and strength of recommendation were derived by respective means.

Results The literature review did not reveal trials comparing a treat-to-target approach with another or no strategy, but provided indirect evidence that facilitated the development of recommendations. The task force agreed on 5 overarching principles and 11 recommendations. Based on the current perception and classification of spondyloarthritis (including PsA, axial SpA (AS and non-radiographic axial SpA), peripheral SpA), only the last 2 recommendations are separate for axial spondyloarthritis, peripheral spondyloarthritis and PsA, while principles and 9 of the recommendations form a common trunk for all types of spondyloarthritis. The main treatment target, which should be based on a shared decision with the patient, was defined as remission, with an alternative target being low disease activity. Means to assess disease activity are discussed. Regular follow-up examinations should safeguard the evolution of disease activity toward the targeted goal. Additional items relate to extraarticular and extramusculoskeletal aspects and other factors, such as comorbidity. While the level of evidence was low for all items, the mean strength of recommendation was 9-10 (10: maximum agreement) for all recommendations. A research agenda was formulated.

Conclusions The recommendations shall inform patients, rheumatologists, dermatologists and other experts as well as other stakeholders about expert opinion that allows reaching optimal outcomes of spondyloarthritis including AS and PsA.

Acknowledgements This work was supported by an unrestricted educational grant from Abbott.

Disclosure of Interest J. Smolen Grant/research support from: Abbott, Consultant for: Abbott, J. Braun: None Declared, M. Dougados: None Declared, P. Emery: None Declared, O. FitzGerald: None Declared, P. Helliwell: None Declared, A. Kavanaugh: None Declared, T. Kvien: None Declared, R. Landewé: None Declared, T. Luger: None Declared, P. Mease: None Declared, I. Olivieri: None Declared, J. Reveille: None Declared, C. Ritchlin: None Declared, M. Rudwaleit: None Declared, M. Schoels: None Declared, J. Sieper: None Declared, M. de Wit: None Declared, D. van der Heijde: None Declared

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