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AB0208 Prevalence of anemia and its relationship with disease activity in patients with rheumatoid arthritis: quest-ra study in morocco.
  1. A. Hari1,
  2. S. Rostom1,
  3. R. Lahlou1,
  4. B. Benchekroun1,
  5. L. Benbrahim1,
  6. R. Bahiri1,
  7. N. Hajjaj Hassouni1
  1. 1Rheumatology Hospital Al Ayachi, University Mohamed V of Medicine and Pharmacy, Rabat, Morocco

Abstract

Objectives To evaluate the prevalence of anemia in patients with rheumatoid arthritis and analyze its relationship with parameters of disease activity from the QUEST-RA data Moroccan.

Methods Moroccan QUEST-RA (Quantitative Standard Monitoring Patients with Rheumatoid Arthritis), inspired from Finnish QUEST-RA. Moroccan QUEST-RAis a national multicentric cross-sectional study of patients with rheumatoid arthritis (according to the 1987 ACR criteria) enrolled in public and private sectors, over a period from January 2008 to December 2010. Pre-established questionnaire containing sociodemographic, clinical and paraclinical characteristics was completed by all patients. Patients were divided into two groups: a group with anemia (hemoglobin <13 g / dl in men, <12g/dl in women) and a group without anemia (hemoglobin ≥ 13g/dl in women and ≥ 12g/dl humans) according to the criteria of the World Health Organization. The parameters of disease activity were assessed by EVA patient, EVA doctor, erythrocyte sedimentation rate (ESR), C- Reactive protein (CRP) and DAS-28 ESR.

Results 1129 patients with RA were eligible. The mean age of patients was 48.8 ± 12.7 years with female predominance (87.3%). The median disease duration was 6 years (3-12), the mean DAS28 ESR was 4.94 ± 1.68, the median HAQ was 1 (0.37-1.62). The prevalence of anemia was 28.8%. In univariate analysis, there was a significant association between the presence of anemia, ESR, CRP, HAQ with respectively [(OR = 1.20, 95% CI (1.01-1.40)) (OR = 1.02, 95% CI (1.01 to 1.04)) (OR = 2.07, 95% CI (1.74 to 3.47)) (for all p <0.05)]. Moreover, there was no association between anemia and the presence of comorbidities (ulcer; IDM, vascular pathology ….). In multivariate analysis, only persist an association between anemia, ESR (OR = 1.02, 95% CI (1.01 to 1.06)) and HAQ (OR = 1.04, 95% CI (1.01 to 1.60)) for all p <0.05.

Conclusions This study suggests that the prevalence of anemia was common and appeared to be independently associated with disease activity. Further studies are needed.

Acknowledgements Dr Samir Ahid: Laboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy. Rabat. Morocco.

Disclosure of Interest None Declared

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