Objectives Subclinical atherosclerosis have been demonstrated in patients with early rheumatoid arthritis (ERA) without any signs of cardiovascular disease (CVD). The aim of this study was to investigate the relationship between serum YKL-40 level and arterial stiffness in patients with ERA.
Methods Fourty two patients with ERA and 35 matched healty controls with no history or current sign of CVD were included in the study. ERA patients with active disease, defined as DAS28≥3.2, and symptoms onset <12 months were recruited. Arterial stiffness was evaluated by carotid–femoral pulse wave velocity (CF-PWV), the intima-media thickness carotid (IMT-C) was measured by Carotid ultrasonography. Serum YKL-40 levels were measured by an enzyme-linked immunoassay method.
Results The mean age was 43.1±5.8 years in ERA patients and 41.0±5.9 years in control group. The CF-PWV and IMT-C of the ERA patients was determined significantly higher than the control group (P= .001, P< .001, respectively). YKL-40 levels were significantly elevated in ERA patients than controls (P= .008). The serum levels of YKL-40 in the ERA patients showed a strong correlation with CF-PWV (r= .711, P< .001) and IMT-C (r= .733, P< .001). Multiple linear regression analysis revealed that CF-PWV could only be explained by serum YKL-40 levels (adjusted R2= .493, P< .001)
Conclusions We revealed an association between increased CF-PWV and serum YKL-40 level in patients with ERA. Hence, increased CF-PWV and YKL-40 may be used for early diagnosis of atherosclerosis in early stage of rheumatoid arthritis.
Disclosure of Interest None Declared