Background New treatment options may influence pregnancy outcomes in patients with rheumatoid arthritis (RA), but very few studies after year 2000 have examined rates of spontaneous abortions and stillbirths in rheumatoid arthritis (RA)1,2.
Objectives To examine currently relative risks of spontaneous abortions and stillbirths in RA patients versus references.
Methods Data from the Medical Birth Registry of Norway (MBRN) in the period 1.12.1998 to 31.12.2009 were used to assess relative risks of previous spontaneous abortions (before week 12 of gestation, between weeks 12-22 of gestation) and stillbirths from week 22 of gestation among women diagnosed with RA compared with references. The diagnosis of RA was based on registration of diagnoses in MBRN according to the International Classification of Diseases (ICD)-10. Data on previous spontaneous abortions before gestational week 12 were voluntary self- reported data to MBRN, whereas data on previous spontaneous abortions after week 12 of gestation and stillbirths was obtained by linkage of all the women’s births in the MBRN. For the self-reported data 90 % of patients and references had responded. Poisson regression analyses with adjustment for maternal age at time of last delivery, was applied to estimate relative risks of spontaneous abortions and stillbirths in patients versus references.
Conclusions The risk for spontaneous abortion, both early and late, was significantly higher among patients than references, which is in contrast to most previous studies. The risk of stillbirths did not differ significantly between the groups.
Reed SD, Vollan TA, Svec MA. Pregnancy outcomes in women with rheumatoid arthritis in Washington State. Matern Child Health J 2006;10:361-6
Nørgaard M, Larsson H, Pedersen L et al. Rheumatoid arthritis and birth outcomes: a Danish and Swedish nationwide prevalence study. J Intern Med 2010;268:329-37
Acknowledgements The Medical Birth Registry of Norway (data delivery)
The Liaison Committee between the Central Norway Regional Health Authority and NTNU (financial support)
Disclosure of Interest None Declared