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SAT0429 The Role of Relaxin in Benign Hypermobility Syndrome
  1. S. Em1,
  2. P. Oktayoglu1,
  3. M. Caglayan1,
  4. M. Karakoç1,
  5. D. Ucar1,
  6. M. Bozkurt1,
  7. N. Mete1,
  8. M. A. Sriyildiz1,
  9. K. Nas1,
  10. I. Yıldız1
  1. 1Dicle Universty Faculty of Medicine, Diyarbakir, Turkey

Abstract

Objectives Benign hypermobility syndrome (BJHS) is a clinical entity that characterized with increased joint mobility rather than range of motion in a joint is alternate according to joints surface neuromuscular tonus and neurogenic controls of joints. Prior investigations suggest that there is a significant correlation between ligament laxity and serum relaxin levels. Sourced from thsee findings, we aimed to investigate the serum levels of relaxin in patients with hypermobility syndrome.

Methods 45 female patients with BJHS and 40 healty controls were enrolled to the study. Pregnancy, lactation, usage of oral contraceptive, menstrual cycle disorders, any neurological, rheumatological, musculoskeletal disorders, metabolic or connective tissue diseases were determined as exclusion criters. All patients with BJHS were diagnosed according to the Beighton scoring system. All patients and control subjects’ physical examinations were completed and all finding were noted. Postures of the patients were assessed according to New York Posture Rating Test. Serum relaxin levels both in patients with BJHS and controls were measured and noted.

Results Although serum relaxin levels were high in patients with BJHS, this difference was not statistically significant (47.1 ± 59.3, 34.4 ± 23.9; p> 0.05). We did not determine any correlation between serum relaxin levels and Beighton scores or New York Posture Rating Test. The levels of relaxin in patients with pes planus and hyperkyphositiy were higher than the patients without these clinical parameters (p=0,01 and p=0,05 respectively)

Conclusions Although these results indicate that relaxin has not a major role in patients with BJHS as a circulating hormone, significantly increased levels of relaxin in patients with hyperkyphosity and pes planus suggests that further investigations are needed in respect with relaxin and its receptors.

Disclosure of Interest None Declared

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