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SAT0278 Left Ventricular Dysfunction Assessed by Speckle-Tracking Strain Analysis in Patients With Psoriatic Arthritis Patients without Clinical Evidence of Cardiovascular Disease
  1. B. Yilmazer1,
  2. T. Şahin2,
  3. A. Çefle1
  1. 1Dept. of Internal Medicine, Division of Rheumatology
  2. 2Dept. of Cardiology, Kocaeli University Medical Faculty, Kocaeli, Turkey

Abstract

Objectives Psoriatic Arthritis (PsA) is a chronic inflammatory disorder. Its etiology is unknown and it is associated with psoriasis. Endothelial dysfunction and early atherosclerosis have been found a high prevalence in PsA patients. Few studies have investigated whether there is any early impairment of myocardial function. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with PsA. The aim of this study was to assess, by using the novel technique, the presence of myocardial dysfunction in patients with PsA.

Methods 31 PsA patients without clinical evidence of CVD and 19 matched (age, gender, body mass index, smoking status) healthy control subjects were enrolled. All were undergone by conventional echocardiography, tissue Doppler imaging and speckle-tracking strain analysis.

Results Eight-teen (58%) patients with PsA had evidence of left diastolic ventricular (LV) dysfunction as defined by septal E’<8 cm/s, and/or septal E/E’>15. Thirteen patients (42%) had evidence of subclinical LH hypertrophy. However, all PsA patients had normal left ventricular ejection fraction. In this study, normal value was defined as >55%. Global longitudinal strains (−17.2 ± 2.7% versus −19.3±2%; P < 0.05), circumferential strains (−14.23 ± 3.0% versus −20.3 ± 4.7%; P = 0.0001), and radial strains (29.8 ± 9. 6% versus 46.5 ± 17%; P =0.001) had been impaired in patients with PsA, as compared with controls. Decreased global longitudinal, circumferential and radialstrains were not associated with disease duration, disease pattern and subjects on disease-modifying antirheumatic drugs (DMARDs) or on tumor necrosis factor(TNF)-α in patients with PsA.

Conclusions PsA patients without established CVD have a high prevalence of subclinical LV dysfunction. Speckle-tracking strain analysis can detect subtle myocardial dysfunction in patients with PsA. The use of this novel imaging technique may therefore improve risk stratification and monitoring of the cardiovascular involvement in patients with PsA.

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Disclosure of Interest None Declared

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