Background The musculoskeletal symptoms as well as extra-articular manifestations of ankylosing spondylitis (AS) decrease quality of life and result in significant productivity loss which significantly contributes to indirect costs of AS.
Objectives To assess the impact of AS on sick leave and estimate the productivity loss due to the absenteeism in AS patients.
Methods Consecutive patients with a diagnosis of AS who attended rheumatology outpatient clinics in seven tertiary-care hospitals were evaluated for demographics, disease characteristics, treatment regimens, patient global disease activity (GDA), pain VAS, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath ankylosing spondylitis disease metrology index (BASMI) and European Quality of Life-5 Dimensions (EQ-5D), Data on total days of sick leave in the last three months were used for the estimation of one-year absenteeism. Additionally, the relationships between the sick leave and Pain VAS and BASFI scores were evaluated.
Results A total of 650 AS patients were analyzed. of whom 55% were employed. 59% of the employed patients had reported taking sick leave for a mean period of 17 days per year due to AS, resulting in an annual average cost of 荤412. Patients who reported sick leave due to AS had higher scores of Pain VAS (p=0.0087) and BASDAI (p<0.0001) but lower scores of EQ-5D (p=0.0309) compared to those who did not report sick leave. No differences were observed between the two groups in respect with other indices such as the GDA, BASFI and BASMI.
Conclusions Increased pain and disease activity lead to a decrease quality of life which are all associated with sick leave in AS patients. Annual productivity loss due to sick leave in Turkey is 荤412 per patient.
Acknowledgements This study was sponsored by Pfizer Turkey
Disclosure of Interest N. Akkoc: None Declared, H. Direskeneli: None Declared, H. Erdem: None Declared, A. Gül: None Declared, Y. Kabasakal: None Declared, S. Kiraz: None Declared, B. Durguner Employee of: Pfizer, V. Hamuryudan: None Declared