Article Text

PDF
SAT0022 In Rheumatoid Arthritis, Younger Age at Onset is Associated with a Higher Rate of Remission at 1 Year: Results from a French Cohort of Early Arthritis Patients (Espoir Cohort)
  1. T. Krams1,
  2. A. Ruyssen-Wtrand1,2,
  3. D. Nigon1,
  4. B. Fautrel3,
  5. F. Berenbaum4,
  6. A. Cantagrel1,
  7. A. Constantin1,2
  1. 1Rheumatology, CHU Purpan
  2. 2UMR 1027, INSERM/UPS Toulouse III, Toulouse
  3. 3Rheumatology, Hôpital Pitié Salpêtrière
  4. 4Rheumatology, UPMC, AP-HP Hôpital Saint Antoine, Paris, France

Abstract

Background Rheumatoid arthritis (RA) is a chronic disease characterized by a peak incidence in the fourth and fifth decades of age. Despite several cross-sectional and a few prospective studies, it has not been clearly established whether there are important clinical differences between early-onset and late-onset RA.

Objectives To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.

Methods The ESPOIR cohort is a longitudinal, prospective, multicenter, observational study that included adult patients with early arthritis. Patients fulfilling the 2010 ACR/EULAR criteria for RA over the first 3 years of follow-up were selected for the present study (n=698). Patients were pooled into 3 groups according to their age at RA onset: <45 years (early-onset [EORA], n=266), 45 to 60 years (intermediate-onset [IORA], n=314) and >60 years (late-onset [LORA], n=118). The following outcomes were compared at baseline and over the first 3 years of follow-up according to the age at disease onset: SDAI remission rate, total Sharp score and HAQ-DI score.

Results The main baseline characteristics of RA patients were as follows: median (IQR) age = 50.3 (39.8-57.2) years, female = 78.2%, median (IQR) SDAI = 28.5 (20.6-38.6), median (IQR) HAQ-DI score = 1 (0.5-1.5), RF+ = 53%, ACPA+ = 45%. Outcomes of interest are shown at baseline and over the first 3 years of follow-up according to the age at disease onset (Table).

Conclusions In a cohort of early RA patients, a younger age at disease onset is associated with a higher rate of remission at 1 year, a lower radiographic score at baseline and thereafter over the 3-year follow-up period and a lower functional score at 1 year and thereafter over the 3-year follow-up period. The analysis of the potential impact of treatment modalities on these age-related differences is under process.

Disclosure of Interest None Declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.