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SAT0022 In Rheumatoid Arthritis, Younger Age at Onset is Associated with a Higher Rate of Remission at 1 Year: Results from a French Cohort of Early Arthritis Patients (Espoir Cohort)
  1. T. Krams1,
  2. A. Ruyssen-Wtrand1,2,
  3. D. Nigon1,
  4. B. Fautrel3,
  5. F. Berenbaum4,
  6. A. Cantagrel1,
  7. A. Constantin1,2
  1. 1Rheumatology, CHU Purpan
  2. 2UMR 1027, INSERM/UPS Toulouse III, Toulouse
  3. 3Rheumatology, Hôpital Pitié Salpêtrière
  4. 4Rheumatology, UPMC, AP-HP Hôpital Saint Antoine, Paris, France


Background Rheumatoid arthritis (RA) is a chronic disease characterized by a peak incidence in the fourth and fifth decades of age. Despite several cross-sectional and a few prospective studies, it has not been clearly established whether there are important clinical differences between early-onset and late-onset RA.

Objectives To investigate whether age at disease onset determines clinical, radiographic or functional outcomes in a cohort of early RA.

Methods The ESPOIR cohort is a longitudinal, prospective, multicenter, observational study that included adult patients with early arthritis. Patients fulfilling the 2010 ACR/EULAR criteria for RA over the first 3 years of follow-up were selected for the present study (n=698). Patients were pooled into 3 groups according to their age at RA onset: <45 years (early-onset [EORA], n=266), 45 to 60 years (intermediate-onset [IORA], n=314) and >60 years (late-onset [LORA], n=118). The following outcomes were compared at baseline and over the first 3 years of follow-up according to the age at disease onset: SDAI remission rate, total Sharp score and HAQ-DI score.

Results The main baseline characteristics of RA patients were as follows: median (IQR) age = 50.3 (39.8-57.2) years, female = 78.2%, median (IQR) SDAI = 28.5 (20.6-38.6), median (IQR) HAQ-DI score = 1 (0.5-1.5), RF+ = 53%, ACPA+ = 45%. Outcomes of interest are shown at baseline and over the first 3 years of follow-up according to the age at disease onset (Table).

Conclusions In a cohort of early RA patients, a younger age at disease onset is associated with a higher rate of remission at 1 year, a lower radiographic score at baseline and thereafter over the 3-year follow-up period and a lower functional score at 1 year and thereafter over the 3-year follow-up period. The analysis of the potential impact of treatment modalities on these age-related differences is under process.

Disclosure of Interest None Declared

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