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FRI0596-HPR The efficacy of aerobic high-intensity interval training on disease activity in patients with ankylosing spondylitis: a proof of concept randomized controlled trail
  1. S. Halvorsen1,2,
  2. K. B. Hagen1,2,
  3. C. Fongen1,
  4. I. J. Berg1,
  5. S. A. Provan1,
  6. T. Ueland3,
  7. P. Aukrust3,
  8. N. Vøllestad2,
  9. H. Dagfinrud1,2
  2. 2University of Oslo
  3. 3Oslo University Hospital, Oslo, Norway


Background Exercise is recommended for patients with ankylosing spondyltis (AS). Yet, the efficacy and safety of aerobic high-intensive training has not been investigated in this patient group.

Objectives To assess the safety (disease control) and efficacy of aerobic high-intensive training on disease activity in patients with AS.

Methods In a randomized controlled trial, 28 subjects were allocated to either an exercise group (EG) or a control group (CG). The exercise program consisted of aerobic high intensity training 40 minutes three days a week and muscular strength training 20 minutes two days a week for 3 months. Primary outcome was disease activity measured with the AS Disease Activity Scale (ASDAS). Secondary outcome measures were the disease specific Bath AS (BAS) measures (DAI, FI, MI) and several biomarkers of inflammation: interleukin (IL)-6, IL-17A, IL-18, IL-23 assessed by enzyme immunoassays. The training was supervised twice a week to observe any possible adverse effects in disease symptoms.

Conclusions This proof of concept study showed that aerobic high-intensity training was well tolerated by patients with AS and resulted in improvements in disease activity and physical function accompanied by a decrease in IL-23.

Disclosure of Interest None Declared

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