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FRI0564 Serious malformations and perinatal deaths in children of patients with rheumatic diseases observed in a national birth registry during 40 years
  1. M. Wallenius1,2,
  2. K. Å. Salvesen3,4,
  3. A. K. Daltveit5,6,
  4. J. F. Skomsvoll2
  2. 2Dept. of Neuroscience, Norwegian University of Science and Technology
  3. 3Dept. of Laboratory Medicine, Women’s and Child Health, Trondheim, Norway
  4. 4Dept. of Obstetrics and Gynecology, Clinical Sciences, Lund University, Lund, Sweden
  5. 5Department of Public Health and Primary Health Care, University of Bergen
  6. 6Medical Birth Registry of Norway, Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway


Background Data on congenital malformations and perinatal deaths in children of patients with inflammatory rheumatic diseases are more seldom published due to lack of large enough data sets.

Objectives To study the occurrence of serious malformations and perinatal deaths in two subgroups with inflammatory rheumatic disease versus references from the general population

Methods Medical data on all births in Norway since 1967 has been recorded in the Medical Birth Registry of Norway (MBRN). We used data from MBRN in the period 1967 – 2009 to assess the occurrence of serious malformations and perinatal deaths in children of patients with specified arthritis (SA) and connective tissue diseases (CTDs), respectively. The SA group constituted patients with rheumatoid arthritis, ankylosing spondylitis and juvenile idiopathic arthritis. The CTD group included patients with systemic lupus erythematosus, Sjøgren’s disease and mixed connective tissue disease. References were all other deliveries registered in MBRN during the same period where the mother was not recorded with an inflammatory rheumatic disease. The diagnoses were based on registrations in MBRN according to International Classification of Diseases (ICD)-8 (1967-1998) and ICD-10 from 1999 and onwards. Birth defects included serious (major) malformations in any organ system and were defined according to a definition by MBRN based on ICD-8 (1967-1998) and ICD-10 (1999 and onwards). All serious congenital anomalies were grouped together as one entity. Perinatal mortality included stillbirths (≥22 weeks of gestation) and early neonatal deaths (0-6 days) in live born children. Associations between the rheumatic diseases and adverse outcomes were assessed in logistic regression analyses with adjustments for maternal age at delivery and parity.

Conclusions Serious malformations were more often observed among children of patients with SA and CTD compared with references and highest among CTD patients. Children of CTD patients had three times higher risk of perinatal death compared with references. In the SA group no higher risk of perinatal death was observed.

Acknowledgements The Medical Birth Registry of Norway (data delivery)

The Liaison Committee between the Central Norway Regional Health Authority and NTNU (financial support).

Disclosure of Interest None Declared

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