Background Systemic lupus erythematosus (SLE) is associated with high cardiovascular mortality. We aimed to evaluate subclinical left ventricular (LV) systolic dysfunction in patients with SLE, without any cardiovascular disease and with normal LV ejection fraction (EF), by using a strain imaging method, “speckle tracking echocardiography” (STE). We also performed a real time three dimensional (3 D) echocardiography in order to demonstrate LV volumetric analysis.
Methods We studied 32 patients with SLE and 20 age and sex-matched controls, without any cardiac disease and with preserved LV EF. Conventional echocardiography, real time 3 D echocardiography and STE- based strain imaging were performed to analyze subclinical LV systolic function
Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. Additionally, LV end-diastolic volume (LV EDV) (100±16.98 ml vs 105±20.06 ml, p=0.37) and end-systolic volume (LV ESV) (37.13±8.10 ml vs 37.47±5.43 ml, p=0.83) measurements by 3 D echocardiography were similar between the patients and the healthy controls. However, LV longitudinal peak systolic strain (13.42±1.93 % vs 17.60±2.18 %, p=0.0001) and strain rate (0.85±0.28 1/s vs 1.35±0.29 1/s, p=0.0001) were significantly impaired in patients with SLE, compared to controls, demonstrating subclinical ventricular systolic dysfunction. There was no correlation between acute phase response, SLEDAI and echocardiographic parameters.
Conclusions Real time 3D echocardiography is a new promising modality allowing for accurate measurement of LV volumetric analysis. Strain imaging-based novel echocardiographic techniques may provide additional data for detecting early deterioration of ventricular systolic function in patients with SLE.
Disclosure of Interest None Declared
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