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FRI0477 Validity of contrast-enhanced ultrasound (CEUS) in the detection of synovial inflammation in rheumatoid arthritis compared to power doppler in contrast-enhanced mri controlled pilot study
  1. B. Raffeiner1,2,
  2. A. Coran3,
  3. L. Bernardi1,
  4. C. Botsios1,
  5. E. Grisan4,
  6. V. Beltrame3,
  7. A. Faccinetto3,
  8. G. Costantini3,
  9. R. Stramare3,
  10. L. Punzi1
  1. 1Rheumatology Unit, Department of Medicine, University of Padova, Padova
  2. 2Rheumatology Internal Medicine, General Hospital Bolzano, Bolzano
  3. 3Radiology Unit, Department of Medicine
  4. 4Department of Information Engineering, University of Padova, Padova, Italy

Abstract

Background The treatment of rheumatoid arthritis (RA) aims clinical remission and arrest of radiological damage. Clinical evaluation alone results inadequate in assessing disease activity, and imaging studies have become integrative assessment tools (1). Power Doppler (PD) allows easy and immediate validation of persistent disease activity, but Contrast-enhanced ultrasound (CEUS) shows higher sensitivity than PD in detecting residual synovial inflammation (2,3). Despite CEUS is easy, fast to perform and contrast agent is innocuous, optimal application is limited to one joint and right joint to evaluate may be missed.

Objectives To demonstrate validity of CEUS to detect synovial activity compared to PD on patient-based indication controlled by contrast-enhanced MRI (CE-MRI).

Methods 32 patients diagnosed with RA where asked to indicate most active felt hand joint. On this joint first PD study was performed by experienced rheumatologist with 12-18 MHz linear probe on Esaote MyLab70 using grading score 0-3 and second CEUS study was performed after injection of contrast bolus (Sonovue®) on Esaote MyLab 25 with CnTI evaluated by 3 different radiologists using grading score 0-2. As control all patients performed CE-MRI and synovitis was graded 0-3 for all joints by experienced radiologist. Results of CEUS and PD on most active joint indicated by patient were referred to CE-MRI.

Results In all 32 cases most active joint felt by patient was joint with highest synovitis grade on CE-MRI (100%). It was the wrist in 53,2% of cases, a metacarpophalangeal in 31,2% and proximal interphalangeal joint in 15,6%. CEUS revealed active synovitis in this side in all cases; sensitivity resulted 100%. Interoperator agreement in assessing CEUS grade was highly significant (kappa=0,83). PD showed inferior sensitivity with false negative assessment in 28,2% of patients. PD and CEUS grade did not correlate significantly with synovitis grade of CE-MRI, although median values were different between CEUS grade 1 and grade 2. Low number of patients may inhibit statistical significance.

Conclusions CEUS confirms higher sensitivity compared to PD in detecting synovitis. Patients’ discomfort only is effective to identify joint for CEUS assessment.

References

  1. Brown AK, Conaghan PG, Karim Z, Quinn MA, Ikeda K, Peterfy CG, Hensor E, Wakefield RJ, O’Connor PJ, Emery P. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum 2008;58(10):2958-67.

  2. Stramare R, Raffeiner B, Ciprian L, Scagliori E, Coran A, Perissinotto E, Fiocco U, Beltrame V, Rubaltelli L. Evaluation of finger joint synovial vascularity in patients with rheumatoid arthritis using contrast-enhanced ultrasound with water immersion and a stabilized probe. J Clin Ultrasound 2012;40(3):147-54.

  3. Klauser A, Demharter J, De Marchi A, Sureda D, Barile A, Masciocchi C, Faletti C, Schirmer M, T Kleffel T, Bohndor K. Contrast enhanced gray-scale sonography in assessment of joint vascularity in rheumatoid arthritis: results from the IACUS study group. Eur Radiol 2005; 15: 2404-10.

Disclosure of Interest None Declared

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