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FRI0452 Determinants factors of sleep disturbances in spondylarthritis
  1. W. B. bousselmi1,
  2. I. M. mahmoud1,
  3. O. S. saidène1,
  4. H. S. sahli1,
  5. R. T. tekaya1,
  6. L. A. abdelmoula1,
  7. L. C. chaabouni1,
  8. R. Z. zouari1
  1. 1rheumathologie, charles nicole hospital, tunis, Tunisia


Background Literature data suggest that sleep disturbances are prevalent among patients with Spondylarthritis (Spa) and have a close correlation with pain and psychological status.

Objectives our study was designed first to evaluate sleep disturbances in patients with Spa and to compare the results to a population of healthy subjects. Secondly, to assess the association of sleep disturbance with demographic variables, pain, tiredness, disease-specific variables, functional status in Spa patients.

Methods This is a case-control Transversal Study that included 70 patients with Spa and 50 healthy subjects. The demographic and clinical characteristics of the patients were collected (The BASDAI (Bath ankylosing spondylitis disease activity index), the BASFI (Bath ankylosing spondylitis functionnal index), the BASMI (Bath ankylosing spondylitis metrological index), BAS G (Bath ankylosing spondylitis Global index), the BASRI (bath ankylosing spondylitis radiology index). Depression or anxiety was evaluated by the HAD (hospital anxiety and depression scale) and quality of life was assessed by the SF36(Summary physical (PCS) and mental (MCS) component measure). Sleep quality was evaluated by sleep scale from the medical outcomes study. The 12 items of the MOS Sleep Scale measure sleep parameters across six domains (sleep disturbance, sleep adequacy, sleep quantity, somnolence, snoring and shortness of breath, or headache).

Results There were 65% men and 35% women. Age ranged from 16 to 74 years with an average of 40,6 years. Disease mean duration was 10,75±9 years. Mean Pain-VAS was 65 mm and mean Tiredness-VAS was 56 mm. Mean BASDAI score was 45%, mean BASFI score 44,7% and mean BASG-s score 55%. The mean BASMI score was 4,76 and the mean BASRI score was 4,43. Mean HADS score was 15,9. Sleep disturbance is correlated with the VAS pain (p = 0.027), the VAS fatigue (p = 0.006), the BASDAI (p = 0.03), the BASFI(p=0,048), the BASG (p = 0.01), the HAD (0.002 ) and inversely correlated with PCS(p=0,02) and MCS(p=0,006). The quantity of sleep is inversely correlated with the VAS pain (p = 0.005), the VAS fatigue, BASDAI (p = 0.02), the BASG (p = 0.002), the HAD (p = 0.004) and Lesquene index (p = 0.015) and correlated to the PCS(p=0,042) and MCS(P=0,002). The results for the comparative study of sleep disturbances between spa and healthy and are summarized in the table

Conclusions our study suggests that sleep disturbances are frequent and severe in the Spa. Our findings suggest that multiple factors are associated with polysomnographic sleep disturbances including disease activity, fatigue, hips involvement and anxiety and depression.

Disclosure of Interest None Declared

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