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FRI0443 Bone loss in patients with early spondyloarthritis
  1. E. E. Gubar1,
  2. A. G. Bochkova1,
  3. A. V. Smirnov2,
  4. T. V. Dubinina3,
  5. A. B. Demina3,
  6. O. A. Krichevskaya3,
  7. O. A. Rumyantseva1,
  8. S. V. Shubin1,
  9. E. V. Volnukhin3,
  10. S. F. Erdes3
  1. 1Laboratory of Seronegative Spondyloarhtitis
  2. 2Department of Radiology
  3. 3Department of Medico-Social Investigations, Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Objectives To examine bone mineral density (BMD) at the femoral neck and lumbar spine and to look for the association between bone loss and disease activity in patients with early spondyloarthritis (SpA).

Methods 30 pts (14 men and 16 women) with early SpA were included in this study; mean age 28.9±6.3 years, disease duration <24 months (15.3±8.1), mean BASDAI 4.4±3.9. Clinical data were collected and BMD was measured using dual energy X-ray absorptiometry (DXA) of the femoral neck and lumbar spine. Magnetic resonance imaging (MRI) of the sacroiliac joints (SIJs), and lumbar spine (L2–4) was performed.

Results The reduction in BMD was found in 18 (60%) pts. All of them had osteopenia (-1>T-score>-2.5). 6 pts (20%) had osteopenia of lumbar spine, 4 pts (13.3%) had osteopenia of the femoral neck, osteopenia in both areas was found in 8 pts (26.7%). In all pts with osteopenia mean T-score was -1.68±0.47 at the femoral neck and -1.92±0.46 for the lumbar spine.

Femoral neck and/or lumbar spine bone loss was found to be associated with bone marrow oedema of the SIJs and/or lumbar spine (p=0.029). No association was found between bone loss and raised C-reactive protein levels (p=0.184) or high disease activity according to BASDAI scores (p=0.703).

Conclusions MRI bone marrow oedema of the SIJs and lumbar spine was found to be associated with bone loss in lumbar spine and femoral neck.

Disclosure of Interest None Declared

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