Objectives To assess the value of disease-specific LupusQoL questionnaire and compare it with a general QoL scale, SF36, in patients with SLE from Turkey.
Methods Patients with SLE followed in the Rheumatology Clinics (F/M: 87/2, mean age: 40,9±1,2 years, mean disease duration: 8,5±6,8 years) were enrolled to the study. All patients were asked to complete a LupusQoL questionnaire, Short Form 36 (SF-36) and hospital anxiety and depression scales. Data were analyzed using SPSS16 program.
Results A total of 89 patients were included and 27% (n= 24) of these were active. Mean SLEDAI score was 3,17±4,36, mean LupusQoL score was 59,15±2,44 and mean SF36 score was 46,29±1,77. There was a significant correlation between LupusQoL and SF36 global scores (r=0,623, p=0.000). SLEDAI scores and SF36 (r=-0,297, p=0,005) also correlated. However, no significant correlation between SLEDAI and LupusQoL scores were observed (r=-0,05, p=0,689). Longer education time period correlated with a higher LupusQoL and SF36 scores (p=0,01). Both lupusQoL and SF36 scores of patients with high anxiety and depression scores (cut-off ≥ 10 for anxiety and ≥ 7 for depression score) were also observed to be lower (Mean SF36 global score: anxiety: 38,33±10,36 vs. 50,12±16,41 and depression: 38,42± 9,61 vs. 52,13± 16,81 and mean LupusQoL score: anxiety: 35,81±15,08 vs. 68,78± 20,77 and depression: 41,92± 19,33 vs. 71,99± 19,45, all p<0,05).
Conclusions LupusQoL and SF36 have the similar efficiency for measuring quality of life in patients with SLE. However, SLEDAI scores were not associated with LupusQoL and SF36, suggesting that QoL in these patients might be affected by other factors beside the disease activity, such as anxiety and depression.
Disclosure of Interest: None Declared