Background Introduction: The metabolic syndrome (MS) is a cluster of the most dangerous risk factors for cardiovascular disease and type 2 diabetes, which include abdominal obesity, high cholesterol, high blood pressure, diabetes or raised fasting plasma glucose. Metabolic syndrome is a risk factor that increases cardiovascular morbidity and mortality in adults and increased morbidity in children and adolescents. The prevalence of metabolic syndrome in healthy Mexican adolescents it had been reported up to 13% according International Diabetes Federation (IDF).
Objectives Objective: To investigate the prevalence of metabolic syndrome in a pediatric population with SLE and its association with lupus activity versus healthy controls.
Methods Patients and methods: we studied 37 children (women 32 and men 5) with SLE and 100 healthy children (women 48 and men 52) with age between 10 to 16 years old and complete clinical charts. Exclusion criteria: primary antiphospholipid syndrome, overlap syndrome of connective tissue disease, patients in treatment with drugs to decrease lipids and glucose. The following were determined: total cholesterol (TC), high density cholesterol (HDLc), triglycerides, glucose, antinuclear antibodies, blood cell count and somatometry. For the diagnosis of MS we applied the criteria of the IDF and for the SLE activity we used Mex-SLEDAI.
Results Results: There were 37 children with age of 12.2±1.9 year and control 12.1 ± 1.5 year. The mean evolution time of SLE was 2.8±2.5 years. MS was found in 11 of 37 (32%) versus control 11 of 100 (10.78%), p = 0.0021. When we analyzed the components of the MS we find statistical differences in triglyceride levels 151 mg/dl [71-504 mg/dl] vs 91 mg/dl [32-504 mg/dl] (p= 0.0001), arterial hypertension according to age and gender percentile (>95) we found 19 of 37 (37.14%) in SLE patients vs 16 of 100 ( 15.6%) healthy control, (p=0.0037) and glucose levels 79.05 mg/dl + 10.82mg/dl vs 83.7 mg/dl + 7.31 mg/dl (p=0.0001) respectively. We did not find statistical significance between SLE activity and metabolic syndrome with active SLE 31.03% versus 37.5% cases with non active SLE (p= 0.47)
Conclusions Conclusion: The prevalence of MS in Mexican pediatric patients with SLE was 32% in comparison with healthy children in 11%. The MS was not associated with SLE activity. It is important to identify children with SLE and MS, implementing therapeutic strategies for the prevention of diabetes or cardiovascular disease in the future.
Disclosure of Interest: None Declared
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