Objectives To compare histological and serological features and clinical manifestations of Primary Sjögren`s Syndrome (pSS) diagnosed at the elderly age to those diagnosed at an early age.
Methods It was analyzed GESSAR’s (Argentine Study Group of Sjögren’s Syndrome) data base of patients diagnosed with pSS according to 2002 American-European criteria, older than 18 years of age. It was used the chi-square test or Fisher’s exact test for categorical variables, according to the expected frequency distribution table. It was performed a logistic regression multivariate analysis.
Results Out of 330 patients, 236 were diagnosed under the 60 years of age (Group 1) and the remaining 94 were diagnosed over 60 years of age (Group 2). There were no significant differences regarding gender in both groups (95% vs. 98.7% were women in groups 1 and 2 respectively; p:0.361). The patients’ median age at the time the diagnosis was made was 47 in group 1 (riq: 37-54), 67 years of age in group 2 (riq: 63-70). The median age at the onset of the symptoms was 41 in group 1 (riq: 31-51) and 64 in group 2 (riq: 58-69). We found significant differences between both groups regarding xerostomia, 215 (91,4%) vs 92 (97%): p 0.048; pulmonary fibrosis, 4 (1,9%) vs 7 (8,33%): p 0.014; antinuclear antibodies, 196 (86%) vs 67 (74%): p 0.01; Anti Ro 183 (78.8%) vs 57 (64.6%): p 0.009 and Anti La 122 (53,5%) vs 31 (35,6%): p 0.005; respectively.
We did not find significant differences between both groups regarding the following variables: xerophthalmia (p: 1.0), parotid gland enlargement (p: 0.86), arthralgias (p: 0.82), arthritis (p: 0.10), purpura (p: 0.98), Raynaud’s syndrome (p: 0.39), active interstitial pneumonia (p: 0.15), renal tubular acidosis (p: 0.62), glomerulonephritis (p: 1.0), peripheral neuropathy (p: 0.19), lymphoma (p: 0.36), leukopenia (p: 0.78), anemia of chronic diseases (p: 0.85), polyclonal hypergammaglobulinemia (p: 0.28) and Rheumatoid Factor (p: 0.37). In the multivariate analysis, only the anti La was associated in a significant and independent way with the age at the time of the diagnosis (OR: 0.48. IC95%: 0.29-0.80, p: 0.005).
Conclusions pSS diagnosed under the 60 years of age presented more frequency of seropositivity of the ANA, anti Ro and anti La with a statistically significant difference. In the group diagnosed over the 60 years of age, the xerostomia and the pulmonary fibrosis were significantly more frequent.
Disclosure of Interest: None Declared