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FRI0285 Prognostic factors associated with mortality in pediatric systemic lupus erythematosus (SLE).
  1. L. M. Suárez-Larios1,
  2. E. Faugier-Fuentes2,
  3. R. Maldonado-Velázquez2,
  4. M. U. Martinez Martinez3,4
  1. 1Hospital Infantil del Estado de Sonora, Sonora
  2. 2Hospital Infantil de México, Mexico City
  3. 3Unidad de Investigaciones Reumatológicas, Hospital Central “Dr. Ignacio Morones Prieto”, Universidad Autónoma de San Luis Potosí
  4. 4Hospital General de Zona No. 1, IMSS, San Luis Potosi, Mexico

Abstract

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with significant morbidity and mortality. Recent studies suggest that childhood-onset SLE is more frequent and severe in nonwhite populations, especially Hispanics.

Objectives To assess the factors associated with mortality in pediatric patients with SLE.

Methods Retrospective cohort. Children and adolescents with SLE admitted to the intensive care unit (ICU) of a single pediatric center in Mexico City from January 1999 to December 2008 were included. We reviewed the medical records of these patients, including age, sex, disease evolution, diagnostic criteria, disease activity (MEX-SLEDAI), neurological and kidney disease, nephropathy (histological classification), treatment at admission, reason for ICU admission, days in pediatric ICU, requirement of catecholamines, invasive procedures, complications, reason of death and PRISM score. Statistical analysis: Categorical variables were analyzed with X² test or Fisher`s exact test. Continuous variables were analyzed with Student t-test.

Results Fifty-six patients were included: thirty-two died and 24 survived. Forty-four were women (78.6%) and 12 men (21.4%). Table 1 shows the main clinical characteristics evaluated in our cohort.

Conclusions Mortality in pediatric SLE patients admitted to ICU is the same of that reported in patients admitted with other diagnoses. Factors associated with mortality were the high SLEDAI score, high PRISM score, necessity of catecholamines, glucocorticoids, mechanical ventilation and infections. The main cause of death in our patients was infections.

Disclosure of Interest: None Declared

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