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FRI0281 Cardiac valve abnormalities progression in systemic lupus erythematosus (SLE) patients detected by transthoracic and transesophageal echocardiography (TTE and TEE): 3-year follow-up
  1. L. S. Kholopov1,
  2. O. I. Dyadyk1,
  3. A. E. Bagriy1,
  4. O. V. Samoilova1,2,
  5. O. V. Schukina1,
  6. S. R. Zborovskyy1
  1. 1Postgraduate Education Training, Donetsk National Medical University
  2. 2Diagnostic Center, Donetsk Regional Clinical Territorial Medical Association, Donetsk, Ukraine


Background Valvular heart disease is one of the most typical and prognostically significant cardiac lesions in SLE. It is not generally accepted whether valve lesions in SLE have a progressive or stable pattern [1,2]. In our prospective study we investigate dynamical changes of these abnormalities.

Objectives The aim of our study was to evaluate cardiac valve lesions in SLE pts using TEE in combination with TTE during 3-year follow-up.

Methods TTE was performed in 67 consecutive pts (11M:56F, mean age – 28 yrs) and TEE in 53 of them using Philips HDI 5000 with 2.0-4.0 MHz transducer and EnVisor C with multiplane 5 MHz TEE transducer. TEE was used in pts with inconclusive or controversial TIE data about valve structure [3].

Results Initially cardiac valve lesions were detected in 58 (86.6%) pts. During follow-up observation new abnormalities were revealed in 10 (14.9%) pts (see table). All new valve mass (vegetations) were diagnosed in patients with SLE exacerbation during follow-up.

Conclusions During 3-year follow-up appearance or progression of cardiac valve lesions was detected totally in 18 (26.9) pts. Our data showing the dependence of valve lesion changes in SLE from immunosuppressive therapy need to be confirmed in larger studies.


  1. Leonard Wei-Ren Lan, Cheng-Ting Tsai and Charles Jia-Yin Hou. The Valvular Involvement of Lupus: Congestive Heart Failure Can Be The Presenting Feature of Systemic Lupus Erythematosus / Acta Cardiol Sin 2005;21:111-115.

  2. Fluture A, Chaudhari S, Frishman WH. Valvular heart disease and systemic lupus erythematosus: therapeutic implications / Heart Dis. 2003 Sep-Oct;5(5):349-53.

  3. Roldan CA, Qualls CR, Sopko KS, Sibbitt WL Jr. Transthoracic versus transesophageal echocardiography for detection of Libman-Sacks endocarditis: a randomized controlled study / J Rheumatol. 2008 Feb;35(2):224-9.

Disclosure of Interest: None Declared

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