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FRI0133 Does rheumatoid arthritis predispose to abnormal left ventricular geometry?
  1. H. B. Midtbø1,
  2. E. Gerdts1,2,
  3. I. C. Olsen3,
  4. T. K. Kvien3,
  5. E. S. Davidsen1,
  6. A. G. Semb3
  1. 1Department of Heart Disease, Haukeland University Hospital
  2. 2Department of Clinical Medicine II, University of Bergen, Bergen
  3. 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Abstract

Background Left ventricular (LV) geometry is a strong predictor of cardiovascular death. Less is known about the relation between LV geometry and RA.

Objectives Our objective was to study if RA or RA disease activity was associated with abnormal LV geometry measured as increased LV relative wall thickness (RWT) or mass (LVM).

Methods Echocardiography, clinical and laboratory assessment was performed in 137 RA patients without prior myocardial infarction or valvular disease and 50 healthy controls. Age-adjusted RWT and LVM were calculated by validated equations.

Results The RA group was older, had higher blood pressure (BP) and included more women compared to controls (all p<0.01). Among RA patients, higher RWT correlated with higher systolic BP, wall stress, and RA disease activity measured by modified health assessment questionnaire (MHAQ), Clinical Disease Activity Index (CDAI), simple DAI (SDAI) and Disease Activity Score in 28 joints (DAS-28) in univariate analyses (all p<0.05). Wall stress and systolic BP were the main covariates of higher RWT in multivariate analyses both among RA patients and controls (all p<0.01). However, the analyses showed that among RA patients, RWT was associated with 4 different disease activity measures independently of gender, systolic BP and wall stress (Table). Higher LVM was independently associated with higher systolic BP, age and body weight, male gender and lower LV ejection fraction (all p<0.05), but was not associated with markers of RA disease activity.

Conclusions Abnormal LV geometry is associated with markers of increased disease activity in RA, independent of systolic BP and wall stress, pointing to the importance of disease activity control in RA patients.

Disclosure of Interest None Declared

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