More than half of the patients with rheumatoid arthritis seen in daily care have one or more comorbid conditions. These may be coincidental medical conditions as expected in the age and sex matched general population. However, many of these disorders share risk factors and pathophysiological pathways with RA, such as smoking, obesity, physical inactivity or periodontal disease. In addition, a number of serious comorbidities are driven by the RA-related inflammation such as lymphomas or cardiovascular disease. Finally, current treatments bear the risk of inducing new comorbidity such as serious infections, cardiovascular, liver, renal or gastrointestinal disease, osteoporosis or autoimmune diseases. There is a complex interaction between treatment and comorbidity since successful control of disease activity is able to reduce the risk of comorbidity and to prolong life expectancy.
During the last year we have gained new insights into the importance of obesity for the development, clinical course and outcomes of RA, on the impact of periodontal disease for systemic inflammation and on several therapy-induced comorbidities. The lecture will give an overview of current concepts of the interaction of risk factors and of methods to assess individual risk.
Disclosure of Interest None Declared