Background Individuals suffering from chronic pain are frequently affected by depression, which in turn increases the risk of development of chronic pain complaints over time.
Objectives This study aims to investigate the relationship between depression and pain intensity and threshold in a cohort of rheumatic patients compared to healthy subjects.
Methods 124 individuals of whom 50 affected by rheumatoid arthritis (RA), 23 by psoriatic arthritis (PsA), 23 by ankylosing spondylitis (AS) and 28 age-matched controls without chronic pain underwent quantitative sensory testing (QST) to assess pressure pain threshold with an algometer. Pain intensity was evaluated through the Visual Analogue Scale (VAS) and depression through the Hamilton Depression rating Scale (HAMD).
Results A significant reverse correlation between HAMD values and algometer scores was found in the entire cohort of patients (p<0.0001), in controls (p=0.002) and also in RA (p=0.002), PsA (p<0.0002) and AS (p=0.02) patients when analyzed separately, while no significant correlation was found between HAMD and VAS values or algometer scores and VAS. We found lower pain thresholds in RA and PsA patients while no difference has been evidenced in AS patients compared to healthy controls. HAMD scores were also significantly higher in rheumatic patients than in controls.
Conclusions The evaluation of chronic pain in patients affected by rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis that display comorbid depression seems more reproducible and reliable with the use of an algometer which, therefore, could be considered an useful instrument in pain/depression overlap management.
Disclosure of Interest None Declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.