Background Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease that affects the populations with certain ethnic backgrounds. It is characterized by self-limiting febrile attacks of polyserositis. In recent years, some studies reported that FMF patients had increased vascular wall alterations and damage which may be another clinical phenotype of the disease. It is suggested that, because its association of inflammasome, the key cytokine in the pathogenesis of FMF is IL-1. Some of the studies also reported increased concentrations of IL-17 which is a key cytokine related with T-helper (Th-17) axis. However, available data regarding these subjects are still limited and additional information is required.
Objectives In the present study, we primary intended to evaluate some of the biomarkers related with vascular injury and cytokines related with Th-17 axis in regularly treated and attack-free FMF patients.
Methods Forty (21 males [M] and 19 females [F], 31 [15-58] years) FMF patients and eighteen healthy controls (11 M and 7 F, 35.5 [19-46] years) with no known cardiovascular (CV) risk factors were included. All patients were receiving regular colchicine treatment and examinations were performed during attack-free periods. Serum samples were used for the determination of high sensitive C-reactive protein (hs-CRP), tissue factor (TF), tissue plasminogen activator (t-PA), osteoprotegerin (OPG), interleukin-6 (IL-6), IL-17, and IL-23. Plasma samples were used for the determination of asymmetric dimethylarginine (ADMA) and thrombomodulin (TM).
Results Age, sex distribution, waist circumference, body mass index, smoking status and serum lipids were similar between the patients and controls (P > 0.05). The concentrations of (hs-CRP) and IL-17 were significantly higher in FMF patients compared to controls (P < 0.05). On the other hand, IL-6 and IL-23 levels were not different between the groups (P > 0.05). ADMA, OPG and TM concentrations were significantly lower in the patients’ group compared to those of controls (P < 0.05). However, vWF, TF and t-PA levels were similar between the groups (P > 0.05).
Conclusions In this study we showed that IL-17 was significantly higher in FMF patients compared to controls. We also revealed that markers related with endothelial injury including ADMA, OPG and TM were significantly down-regulated in FMF patients who were on regular colchicine treatment during attack-free disease state.
Disclosure of Interest None Declared
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