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THU0456 Relapsing Polychondritis : Cases Series in China and Review of the Literature
  1. D. Lin1,
  2. J. Gu1
  1. 1Rheumatology, the 3rd Affiliated Hospital of Sun Yet-sen University, Guangzhou, China

Abstract

Objectives To study the the clinical features of Relapsing polychondritis (RP) in China.

Methods 158 cases from 1994-2012 reported in China were retrospected and compared with international literal reviews[1-8] including clinical features, systemic involvement, differential diagnosis and prognosis.

Results 1)Average age of onset was 45.3 years old, the mean age at first symptoms was 14.4 months and sex ratio was 63 female to 95 male, misdiagnostic rate was as high as 47%. 2) contrast with literal reviews, arthritis was lower frequent than Caucians (18% : 23-47%), but higher than Japaese (5%), while laryngotracheal symptom was higher (42%,14-38%) at the time of diagnosis. The incidence of auricular chondritis(68%: 84% -95%), ocular inflammation (44% :49-65%) were lower during the course of follow-up. Renal (3%: 9% -26%)involvement was lower, and neurological involvement (13%: <10%) were found to be higher in Chinese population. The proportion of associated autoimmune disease and systemic vasculitis were respectively 6%, 3% similar to Japaese (4%, 2%), but less than Caucasians(12-26%,5-18%). The top death cause is respiratory failure due to the primary disease, followed by lung infections and cardiovascular events. Teenager patients(<18yrs) had higher incidence in arthiritis(84%:56%), nasel chondritis(84%:56%), largynochontreal involvement(79%:68%) compared to adult patients in China.

Conclusions Chinese RP had its unique characteristics in spite of sharing most clinical features with the cases series in literature reviews.

References

  1. McAdamLP, O’HanlanMA, BluestoneR, et al. Relapsingpolychondritis:prospective study of 23 patients and a review of the literature. Medicine1976;55(3):193–215.

  2. Suzuki M, Uchida K, Nagano M, et al. Case of relapsing polychondritis associated with persistent rib cartilage pain and severe tracheal stenosis--a review of 53 cases in Japan. Nihon Kyobu Shikkan Gakkai Zasshi. 1983 Jul;21(7):665-71. Japanese.

  3. Michet CJ Jr, McKenna CH, Luthra HS, et al. Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med, 1986,104:74-78

  4. Chang-Miller A, Okamura M, Torres VE, et al. Renal involvement in relapsing polychondritis. Medicine (Baltimore). 1987 May;66(3):202-17.

  5. Francès C, el Rassi R, Laporte JL, et al. Dermatologic manifestations of relapsing polychondritis. A study of 200 cases at a single center. Medicine (Baltimore). 2001 May;80(3):173-9

  6. Zeuner M, Straub RH, Rauh G, Albert ED, Scholmerich J, Lang B. Relapsingpolychondritis: clinical and immunogenetic analysis of 62 patients. JRheumatol 1997;24(1):96–101. David E.Trentham, Christine H. Le, Relapsing Polychondritis. Ann Intern Med.1998;129:114-122.

  7. David E.Trentham, Christine H. Le, Relapsing Polychondritis. Ann Intern Med.1998;129:114-122.

  8. Alexandre Belot, Agnes Duquesne, Chantal Job-Deslandre, et al. Pediatric-Onset Repalsing Polychondritis: Case Series and Systematic Review.

Disclosure of Interest None Declared

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