Objectives To study the the clinical features of Relapsing polychondritis (RP) in China.
Methods 158 cases from 1994-2012 reported in China were retrospected and compared with international literal reviews[1-8] including clinical features, systemic involvement, differential diagnosis and prognosis.
Results 1)Average age of onset was 45.3 years old, the mean age at first symptoms was 14.4 months and sex ratio was 63 female to 95 male, misdiagnostic rate was as high as 47%. 2) contrast with literal reviews, arthritis was lower frequent than Caucians (18% : 23-47%), but higher than Japaese (5%), while laryngotracheal symptom was higher (42%,14-38%) at the time of diagnosis. The incidence of auricular chondritis(68%: 84% -95%), ocular inflammation (44% :49-65%) were lower during the course of follow-up. Renal (3%: 9% -26%)involvement was lower, and neurological involvement (13%: <10%) were found to be higher in Chinese population. The proportion of associated autoimmune disease and systemic vasculitis were respectively 6%, 3% similar to Japaese (4%, 2%), but less than Caucasians(12-26%,5-18%). The top death cause is respiratory failure due to the primary disease, followed by lung infections and cardiovascular events. Teenager patients(<18yrs) had higher incidence in arthiritis(84%:56%), nasel chondritis(84%:56%), largynochontreal involvement(79%:68%) compared to adult patients in China.
Conclusions Chinese RP had its unique characteristics in spite of sharing most clinical features with the cases series in literature reviews.
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Disclosure of Interest None Declared
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