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THU0384 Juxtaarticular Osteoporosis Exists in the Wrist Joint from the Early Stage of Rheumatoid Arthritis
  1. H. Ito1,
  2. M. Furu1,
  3. M. Hashimoto1,
  4. T. Fujii1,
  5. N. Yamakawa2,
  6. C. Terao3,
  7. T. Mimori2
  1. 1Department Of The Control For Rheumatic Diseases
  2. 2Department of Rheumatology and Clinical Immunology
  3. 3Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan


Background Juxtaarticular osteoporosis is considered a unique feature, especially in the finger joints, in patients with rheumatoid arthritis (RA). However, there is little evidence from when it exists, and few reports showed the differences or similarities between juxtaarticular and general osteoporosis.

Objectives To investigate from when juxtaarticular osteoporosis exists in the wrist joint and whether it differs from general osteoporosis in patients with rheumatoid arthritis (RA).

Methods In 177 patients with RA, 24 were male, and 153 were female. The averages of age and the duration of the disease were 62.2 and 16.3 years. The DAS28 was 3.18, and HAQ was 0.89 in average. The ratios of biologics, MTX, and steroid users were 26.8%, 66.2%, and 39.1%, respectively. Dual-energy X-ray absorptiometry was performed in the patients at the left sides of distal radius and the proximal femur and was evaluated by the young adult mean (YAM) value. Only the data of female patients was analyzed.

Results The total value of the distal radius was 71.5±18.3 in average, relatively lower than that of the proximal femur (79.8±13.6). The average values of UD (71.1±19.5) and MID (70.0±19.8) of the distal radius were relatively lower than that of 1/3 (77.6±21.3). The value of MID and 1/3 were negatively correlated with the duration of the disease, respectively (p<0.01), while that of UD was not. Significant difference was not observed between the values of UD of the early stage (less than 3 years after the onset of the disease) and the late stage (more than 15 years) of the patients.

Conclusions Juxtaarticular osteoporosis in the wrist joint exists from the early stage of the disease.

Disclosure of Interest None Declared

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