Objectives To evaluate lumbar spine and femoral neck bone mineral density (BMD) and T score at lumbar and femoral neck levels in documented coronary artery disease patients.
Methods We studied spine and femoral neck bone mineral density in 68 angiographically documented coronary artery disease patients (narrowed main coronary vessels more than 50%) and 42 persons with normal angiography. Blood lipid profile was determined in all the participants. Both evaluated groups of patients were similar in age, sex and body mass index (BMI). All the received data were analyzed statistically.
Results After final adjustment by age, sex and BMI, we found that severity of coronary artery disease independently correlated with Bone mineral density of femur and of lumbal spine. BMD was significantly lower in patients with coronary artery disease (P= 0.04). Femur osteoporosis and osteopenia was found in 26,7 % of patients with coronary artery disease whereas only 12,3% of people with normal angiography had osteoporosis at the level of femur (P= 0.05, OR= 4.42; CI 95%, 1.29-14, 77). Lumbal spine osteoporosis and osteopenia was found in 27,5% and 11,8 % in people with normal angiography (P= 0.05, OR= 4.13; CI 95%, 1.18-12, 23). We also found a strong indirect correlation between total cholesterol and LDL cholesterol levels and bone mineral density at femoral levels (p<0,05). Cholesterol levels and BMD at lumbar level showed a tendency to correlation. Trigicerides level did not show any statistically significant differences with BMD at any level.
Conclusions We can suppose that coronary artery disease and severity of atherosclerosis may serve as a bone turnover predictor. Thus, recommendation of Bone density measurement to patients with a coronary disease may be valuable for earlier diagnosis and prevention of osteoporosis and fractures. More studies are necessary to elucidate deeper the relationship between osteoporosis and coronary artery disease.
Acknowledgements Department of Interventional Medicine, Institute of Cardiology of the Republic of Moldova
Disclosure of Interest None Declared