Inflammation is a primordial response to infection and injury that seeks to neutralise and eliminate foreign organisms and/or material. Thus, inflammation is no trivial event. Life depends upon it. In general, the innate inflammatory response initiates within minutes and resolves within hours. Chronic inflammation, on the other hand, persists for weeks, months or even years and, unlike the acute response, is the side of host immunity we need to avoid. Notwithstanding, dispersed among this black and white view of inflammation are shades of grey. We are constantly reminded that defining inflammation is not so easy and that while acute inflammation can resolve, it can also be recurrent and that, over time, chronic inflammation can also resolve or persist with devastating consequences to the host. In this presentation, one of these many aspects of the inflammatory response – how acute inflammation resolves and the role of macrophages in this process will be discussed. I will present new data on so-called resolution-phase macrophages, describe their phenotype in the context of conventional nomenclature and speculate on their function in resolution and homeostasis.
Disclosure of Interest None Declared