A number of studies have shown that the symptoms of rheumatoid arthritis (RA) or inflammatory polyarthritis (IP) ameliorate during pregnancy, especially pregnant women who are rheumatoid factor (RF) negative and anti-cyclic citrullinated peptipe antibody (ACPA) negative compared to autoantibody-positive women. Less is known about the influence of pre-symptom or post-symptom onset pregnancies and live births on the long-term disease outcome in women with RA. In addition, the underlying mechanisms of improvement in symptoms during pregnancy and post-partum flare are not disentangled yet, but the role of a number of immunological and hormonal factors have been suggested.

The main aim of this talk is to present the influence of pre-symptom pregnancy, pregnancy, post-partum and post-symptom pregnancy on disease activity in patients with RA and IP.

Disclosure of Interest None Declared