Background Periodontitis (PD) has been suggested to be one of risk factors for rheumatoid arthritis (RA). Porphyromonas gingivalis (P. ginvivalis, Pg) is a gram-negative anaerobic bacterium that is recognized as a major pathogenic organism in periodontitis (PD). Anti-enolase 1 (ENO1) antibody is one of the autoantibodies in RA.
Objectives This study examined the relationship between serum levels of anti-Pg and anti-ENO1 antibodies and PD severity and RA disease activity in patients with RA.
Methods 246 Patients with RA and 85 age-, sex- matched non-RA controls were enrolled in this study. After rheumatologic and periodontal examination, serum levels of anti-Pg antibodies and anti-ENO1 antibodies were measured by enzyme-linked immunosorbent assay (ELISA).
Results Patients with RA showed significantly higher levels of anti-Pg antibodies and, anti-ENO1 antibodies than controls (P= 0.002, P= 0.02). Anti-Pg antibodies were strongly correlated with anti-ENO1 antibodies in RA patients (p<0.0001). In active RA, there were significant correlations between anti-Pg antibodies with probing pocket depth (PPD) and clinical attachment level (CAL) (P= 0.0014, P=0.0059). However, there were no correlations of anti-Pg antibodies and periodontal parameters in controls and inactive RA. Anti-ENO1 titer did not correlate with periodontal parameters except bleeding on probing (BOP) in RA. Anti-Pg antibodies were not correlated with RA disease activity except ESR (p= 0.0357). However anti-ENO1 antibodies were significantly correlated with ESR, DAS28-ESR, anti-CCP titer (P= 0.0008, P= 0.0092, P= 0.0129).
Conclusions Anti-Pg antibodies and anti-ENO1 antibodies were elevated in RA patients than controls. Anti- Pg antibodies were correlated with severity of PD and anti-ENO1 antibodies were correlated with RA disease activity in RA patients.
Disclosure of Interest None Declared