Background The 2010 ACR/EULAR-criteria for RA have been thoroughly studied for the test characteristic but it is unclear whether ‘2010-RA’ has a different phenotype than ‘1987-RA’ when assessing the severity of the disease course.
Objectives Therefore this study compared two long-term disease outcomes in patients classified according to the 2010 ACR/EULAR-criteria and according to the 1987 ACR criteria for RA.
Methods 1502 early arthritis patients that had no other diagnoses than RA or UA were studied on fulfilling the 1987-ACR-criteria, 2010-criteria or both. The severity of joint damage was studied with yearly radiographs over 7-years. Achieving DMARD-free sustained remission was assessed over 10-years follow-up. Multivariate normal regression and Cox-proportional hazard regression were used, adjusting for age, gender and treatment.
Results 550 patients fulfilled the 1987-criteria, 788 patients the 2010-criteria and 489 both criteria sets. Patients fulfilling the 2010-criteria developed less severe radiological joint damage (p=0.023) and achieved DMARD-free sustained remission more often (HR=1.17 (0.93-1.49)) than patients fulfilling the 1987-critera, though the latter was not statistically significant. All 1987+2010-patients were ACPA-negative. When also applying the radiologic criterion of the 2010-criteria half of the 1987+2010- patients became 2010-criteria positive, but results on the long-term outcome remained similar.
Conclusions ‘2010-RA’ has a milder disease course than ‘1987-RA’. This may have important implications for basic scientific studies and clinical trials in RA.
Disclosure of Interest None Declared
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