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OP0183 Long-Term Outcome of Rheumatoid Arthritis Defined According to the 2010-Classification Criteria
  1. J. A. B. Van Nies1,
  2. L. E. Burgers1,
  3. L. Y. Ho2,
  4. D. P. C. de Rooy1,
  5. T. W. J. Huizinga1,
  6. A. H. M. van der Helm-van Mil1
  1. 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands
  2. 2Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, Hong Kong

Abstract

Background The 2010 ACR/EULAR-criteria for RA have been thoroughly studied for the test characteristic but it is unclear whether ‘2010-RA’ has a different phenotype than ‘1987-RA’ when assessing the severity of the disease course.

Objectives Therefore this study compared two long-term disease outcomes in patients classified according to the 2010 ACR/EULAR-criteria and according to the 1987 ACR criteria for RA.

Methods 1502 early arthritis patients that had no other diagnoses than RA or UA were studied on fulfilling the 1987-ACR-criteria, 2010-criteria or both. The severity of joint damage was studied with yearly radiographs over 7-years. Achieving DMARD-free sustained remission was assessed over 10-years follow-up. Multivariate normal regression and Cox-proportional hazard regression were used, adjusting for age, gender and treatment.

Results 550 patients fulfilled the 1987-criteria, 788 patients the 2010-criteria and 489 both criteria sets. Patients fulfilling the 2010-criteria developed less severe radiological joint damage (p=0.023) and achieved DMARD-free sustained remission more often (HR=1.17 (0.93-1.49)) than patients fulfilling the 1987-critera, though the latter was not statistically significant. All 1987+2010-patients were ACPA-negative. When also applying the radiologic criterion of the 2010-criteria half of the 1987+2010- patients became 2010-criteria positive, but results on the long-term outcome remained similar.

Conclusions ‘2010-RA’ has a milder disease course than ‘1987-RA’. This may have important implications for basic scientific studies and clinical trials in RA.

Disclosure of Interest None Declared

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