Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which the aetiology includes genetic and environmental factors. The autoimmune mechanisms of the disease are the potential risk factors for the impairment some brain functions also.
Objectives The goal of the study was to evaluate some cognitive functions belong to the group of executive ones in a group of patients with SLE. Executive functions are related with activity of frontal lobes of brain. The research involved a group of 64 patients with SLE, aged 19-62 yrs, the mean 41,2 yrs, median disease duration 8,3 yrs, the median results in SELENA/SLEDAI 11 points what suggests the moderate activity of the disease. 95% of pts were treated with chlorochine or hydroxychlorochine.
Methods To verify research hypotheses neuropsychological tests such as 10 – word list, direct memory task for sensible words, digit test, test for evaluation the attention – concentration and the ability of sustaining -D2, attention test CTT, language competencies – Fluency Test, Hand Laterality Test, and estimation of the intelligence – Raven Test. Identification and Interpretation of Emotions in Social Situations and Achenbach’s CBCL were used. The research hypotheses were verified by way of Multi – Factor Analysis of Variance (Anova) for quantitative data and Kruskal – Wallis Test for ordinal data while Bonferonni – Dunn Test or Tukey’s HSD were used to find relevant differences between groups. Additionally, in case of nonhomogenous variables, non – parametric tests such as Mann – Whitney Two Sample Test and Kruskal – Wallis Test for three or more samples were applied to verify the result of analysis of variance. For nominal data Chi – square test was used while Pearson r was used to measure the correlation between variables. Ethical approval for data management was obtained from the Ethics Committee of the Poznan University of Medical Sciences.
Results The results show that 14,5% pts with SLE have neurological disorders. Cognitive impairments including direct memory, learning and attention dysfunctions were noticed in 51,6% of all examined pts. In a group with neurological disorders almost all pts revealed low scores in CTT (below 100 sec), the median for Short term memory was 5,6 elements, the median of D2 was below normal scores according to the age of pts. The results of 10 word test was 30, 4 what is low result in comparison to the healthy ones.
Conclusions The model of SLE treatment should include neuropsychological rehabilitation in order to improve patient’s quality of life and to prevent cognitive and social impairments.
Disclosure of Interest None Declared