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I read with interest this paper by van Spil et al1 examining further the osteoarthritis biomarker CTX-II (C-terminal telopeptide of type II collagen) and note the suspicions of the authors that this marker might be linked to bone metabolism. High correlation with biomarkers of bone and CTX-II were noted and also a characteristic increase around the time of the menopause. However, it has been …
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