Statistics from Altmetric.com
Patients with hereditary haemochromatosis (HH) may present arthralgia in the hands and large joints or severe arthropathy mimicking osteoarthritis typically involving metacarpophalangeal (MCP) joints 2 and 3.1–3 This arthropathy, which may seriously affect quality of life, was reported to occur in 20%–50% of HH patients with articular complaints and can coexist with calcium pyrophosphate deposition.4–6
Hand arthropathy is not alleviated by phlebotomy, and in a few patients, disease is refractory or intolerant to standard treatments such as non-steroidal anti-inflammatory drugs (NSAIDs), low-dose colchicine or analgesics. Thus, these patients remain without adequate treatment.
Given the frequent presence of local inflammatory symptoms in MCP joints and the discovery that interleukin 1β (IL-1β) plays a key role in the pathogenesis of arthritis due to …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.