Histopathological correlation supports the use of x-rays in the diagnosis of hand osteoarthritis
- Ilse-Gerlinde Sunk1,
- Love Amoyo-Minar1,
- Birgit Niederreiter1,
- Afschin Soleiman2,
- Franz Kainberger3,
- Josef S Smolen1,
- Klaus Bobacz1
- 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
- 2Department of Pathology, Medical University of Vienna, Vienna, Austria
- 3Department of Radiology and Osteology, Medical University of Vienna, Vienna, Austria
- Correspondence to Klaus Bobacz and Ilse-Gerlinde Sunk, Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; ;
Contributors I-GS: study design, data collection, data analysis, data interpretation, writing of the manuscript. LA-M, BN, AS: data collection. FK: data collection and data interpretation. JSS: study design, data analysis, data interpretation and writing of the manuscript. KB: study design, data analysis, data interpretation, figures and writing of the manuscript.
- Received 18 October 2011
- Accepted 14 April 2012
- Published Online First 12 May 2012
Objective To correlate histopathological and radiographic features of distal and proximal interphalangeal (DIP and PIP) joints in order to test whether the use of an x-ray examination would be beneficial to the classification/diagnosis process of hand osteoarthritis (OA).
Methods DIP and PIP joints were obtained from post mortem specimens (n=40). Plain x-rays of the DIP and PIP joints were taken and radiographic OA was determined by the Kellgren and Lawrence classification. Individual radiographic features were scored according to the method described by Altman. Joint samples were prepared for histological analysis; cartilage damage was graded according to the Mankin scoring system. Spearman's correlation was applied to examine the relationship between histological and radiographical changes. Differences between groups (bony swelling vs no bony swelling) were determined by Student t test.
Results A highly significant correlation was found between histological (Mankin score) and radiographic (Kellgren/Lawrence score) changes in the investigated DIP (rs=0.87, p<0.0001) and PIP (rs=0.79, p<0.0001) joints. A subgroup of patients (37.5% for DIP and 18.8% for PIP joints) showed advanced radiographic changes (Kellgren/Lawrence score ≥2) in joints without clinical bony swelling. Histologically, the mean Mankin scores accounted for 11±1.66 for DIP and 9.67±2.4 for PIP joints.
Conclusion On the basis of histopathological changes of DIP and PIP joints, this investigation demonstrates the validity of x-ray examinations and supports the use of plain radiography in the diagnosis of hand OA and in the classification of hand OA in clinical trials.
Funding This trial was an independent academic study founded by and performed at the Medical University of Vienna.
Competing interests None.
Ethics approval Ethics approval was obtained from the Ethics Committee of the Medical University of Vienna.
Provenance and peer review Not commissioned; externally peer reviewed.