VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis
- Valerie Nell-Duxneuner1,
- Roland Axmann1,
- Emma Husar-Memmer1,
- Tomáš Dallos2,3,
- Christian Datz4,
- Andreas Stadlmayr4,
- Elmar Aigner4,5,
- Matthias Englbrecht3,
- Georg Schett3,
- Jochen Zwerina1,3
- 11st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna, Austria
- 22nd Department of Pediatrics, Comenius University Bratislava, Bratislava, Slovak Republic
- 3Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nurnberg, Nürnberg, Germany
- 4Department of Internal Medicine, Hospital Oberndorf, Oberndorf, Austria
- 51st Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria
- Correspondence to Dr Jochen Zwerina, 1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Hanusch Hospital, Vienna 1140, Austria;
- Accepted 1 April 2013
- Published Online First 18 April 2013
Objectives The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy.
Methods Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures.
Results VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age.
Conclusions VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.