Article Text


Extended report
Results from systematic screening for cardiovascular risk in outpatients with rheumatoid arthritis in accordance with the EULAR recommendations
  1. Jette Primdahl1,
  2. Joan Clausen2,
  3. Kim Hørslev-Petersen3
  1. 1Institute for Regional Health Research, University of Southern Denmark, Hospital of Southern Jutland, Aabenraa and King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark
  2. 2Outpatient Department, King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark
  3. 3Institute for Regional Health Research, University of Southern Denmark and King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark
  1. Correspondence to Jette Primdahl, King Christian X's Gigthospital, Toldbodgade 3, Graasten 6300, Denmark; jprimdahl{at}


Aim To investigate risk factors for the development of cardiovascular disease (CVD) and estimate the risk of cardiovascular death in rheumatoid arthritis (RA) patients in accordance with EULAR recommendations.

Materials and methods Outpatients with RA ≤85 years of age from a Danish hospital were invited to participate. Patients’ risk of cardiovascular death was calculated according to the SCORE system, based on total cholesterol/high-density lipoprotein (HDL) ratio, smoking habits, blood pressure, age and gender. The SCORE was adjusted based on disease duration, IgM-RF/anti-CCP positivity and the presence of extra-articular manifestations. Factors such as history of CVD, hypertension or diabetes mellitus (DM), fasting glucose, exercise habits, body mass index (BMI) and waist circumference were explored.

Results 836 patients participated; 71.5% women; mean (SD) age 64.3 years (12.0); 152 (19.1%) were already diagnosed with CVD and 74 (9.0%) with DM. Among the 644 patients without CVD or DM, 158 (24.5%) were smokers, 229 (35.8%) had a systolic blood pressure ≥140, 397 (65.6%) total cholesterol ≥5.0 mM/L, 326 (55.4%) low-density lipoprotein cholesterol ≥3.0 mM/L, 18 (4.0%) women and 19 (12.1%) men had a HDL-cholesterol level below 1.2/1.0 mM/L. BMI was >25 in 409 (63.8%). Waist circumference was above 80/94 cm in 297 (63.3%) of female and 111 (63.8%) of male patients, respectively, and 418 (64.9%) exercised ≤5 times a week. Among patients without DM, 14.3% had a fasting glucose ≥6.0 mmol/L. The SCORE was ≥5 in 122 (20.2%). They were referred to follow-up by their GP and community advice services.

Conclusions Systematic screening revealed several risk factors that needed medical follow-up or support to initiate lifestyle changes.

  • Cardiovascular Disease
  • Epidemiology
  • Rheumatoid Arthritis
  • Nursing

Statistics from


It is well documented that people with rheumatoid arthritis (RA) have excess mortality compared to the general population, partly due to an increased risk of cardiovascular events and cardiovascular death.1–3 Although people with RA have an increased number of the traditional risk factors for the development of cardiovascular disease (CVD), this does not seem to explain all excess mortality in RA compared to the general population.4 It seems likely that the inflammatory process and disease severity also increases the risk of CVD.4–8 The excess risk posed by having RA may be compared to the risk from having diabetes mellitus (DM) type II,9–11 and is influenced by other disease-related factors and the pharmacological treatment, that is, with glucocorticoids, non-steroidal anti-inflammatory drugs, methotrexate, leflunomide and cyclosporine.12 ,13 Male gender is associated with a greater risk of CVD.14

Longer disease duration, whether the patient is IgM-rheumatoid factor (RF) positive and/or anti-cyclic citrullinated peptide (anti-CCP) positive and the presence of certain extra-articular manifestations seem to be linked with the increased CVD risk due to RA.1 ,15 ,16 In 2010, 10 European League Against Rheumatism (EULAR) recommendations for cardiovascular risk management were published.1 Cardiovascular risk assessment in all patients with RA was recommended. Any identified risks should be managed according to local guidelines, and the patient's risk should be scored according to the SCORE system.17 The risk SCORE should be adapted by a multiplication factor of 1.5 if the patient met two of the following three criteria: disease duration of more than 10 years, RF and/or anti-CCP positivity and the presence of certain extra-articular manifestations18 (pericarditis, pleuritis, Felty's syndrome, polyneuropathy, mononeuritis, scleritis, episcleritis, glomerulonephritis, severe skin vasculitis or vasculitis in other organs). Adequate control of disease activity is also necessary to lower the CVD risk.1

To date, only one study has been identified that reported results from the implementation of the EULAR recommendations for cardiovascular risk management in patients with RA.19 This Spanish study reported risk scores for 200 patients, but included patients with known CVD and DM, even though the SCORE system is not recommended in these patients. Furthermore, the study included rheumatic nodules in the risk assessment, whereas, in the EULAR recommendations, rheumatic nodules are not on the list of extra-articular manifestations that affect the modified SCORE.1 ,18 There is a need for a larger study to assess the impact of risk factors for CVD when implementing the EULAR recommendations.


The objective was to investigate the spread of traditional risk factors for the development of CVD and the risk SCORE for cardiovascular death when implementing the EULAR recommendations for cardiovascular risk management in a Danish hospital population of outpatients with RA.


Implementation of the EULAR recommendations

A multidisciplinary group was established at King Christian X's Hospital for Rheumatic Diseases in Graasten, Denmark, to implement the EULAR recommendations1 for RA outpatients at the hospital. The group defined the aim, the content and planned the delivery of the screening consultations. A set of detailed clinical guidelines was developed based on the EULAR recommendations and national guidelines.1 ,20–22 Screening consultations were to be delivered as 30-min nursing consultations in addition to the patient's normal follow-up visits. The nurses were offered 4 h of training covering CVD and risk management, diet and CVD and opportunities in secondary care for lifestyle change support.


All outpatients with RA 85 years of age or less connected to King Christian X's Hospital for Rheumatic Diseases in Graasten, Denmark, were invited by a standard letter to a screening consultation.

Study design

Before the screening consultation, the patients had their fasting glucose, triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol levels checked.

The patient's habits regarding smoking (smoker/non-smoker), exercise (less than five times a week/five times a week or more), alcohol (below or above the national recommendations of a maximum seven units per week for women and 14 for men) were explored. The patient's height (cm) and weight (kg) were measured with the patient in light clothes and without shoes, and the patient's body mass index (BMI) was calculated as weight (kg) by squared height (m2). Waist circumference (cm) was measured 2 cm above the patients’ umbilicus (midway between the lower rib margin and the iliac crest).14 Blood pressure was measured while the patient was sitting in a chair and after at least 5 min rest.22 If the patient's blood pressure exceeded 5 mm  Hg above the nationally recommended limits, a total of four measures (two on each arm) were performed and the mean of the last two measures was used.22 Each patient's risk SCORE was calculated based on age, gender, smoking habits, systolic blood pressure and total cholesterol/HDL ratio.17 Denmark was considered to be a high-risk area for CVD in Europe when implementing the screening consultations. In accordance with the EULAR recommendations and national guidelines for the management of RA,1 ,23 the risk SCORE was multiplied by 1.5 if the patient fulfilled the above-mentioned criteria. To determine whether the patient had any of the specific extra-articular manifestations, the patient was asked whether a rheumatologist at any time had said that the patient had arthritis apart from in the joints, such as in the eyes, nerves, the vascular system or in other organs. The findings from the screening were discussed with the patient and advice and training in relation to identified risks were offered. Patients were referred to follow-up by the general practitioner (GP) in cases in which the modified risk SCORE was 5% or greater. Patients with blood pressure above the recommended level, total cholesterol above 8 mmol/L or fasting glucose of 6 mmol/L or greater were also referred to their GP. Patients were informed about opportunities to receive additional lifestyle change support in community health centres. Written pamphlets concerning smoking cessation, low-lipid diet and RA were offered.

The patient was offered a page with the actual risk SCORE written on the SCORE chart and the other results from the screening to take home. The findings from the consultations were documented in a Danish rheumatological quality database, the DANBIO registry, and in the patient's journal. Following the consultation, a copy of the note in the journal was sent electronically to the patient's GP. Patients with known DM or CVD or a risk SCORE of 5% or greater will be invited for a follow-up screening visit in 1 year, if they are interested; patients without known DM or CVD and a SCORE of less than 5% will be invited for a new screening consultation in 2 years. Patients over the age of 80 years will only be invited again if they express a wish for a new screening consultation.

Statistical analysis

STATA V.10.1 was used to perform descriptive statistical analyses. Results are reported with mean and SD or median and IQR depending on the distribution of the data. Percentages are calculated based on the number of observations available for each variable.


From September 2011 to November 2012, 836 patients accepted and completed a screening consultation (74.3% of the hospital RA population); 598 (71.5%) were women. Reasons to decline were due to severe disability or co-morbidities, or that it was difficult for them to attend due to transportation or work-related issues. Some patients felt that their GP already took care of the content in the screening consultation or that they did not want to discuss lifestyle issues. Approximately 10% of the patients declined to participate, but the exact number was not recorded.

Patients’ disease activity measured by the disease activity score in 28 joints (DAS28)–C reactive protein (CRP) score24 and physical disability measured by the health assessment questionnaire (HAQ)25 were not recorded in the screening consultations; however, we drew data from an outpatient visit if it was performed within 2 months before or after the screening consultation in order to characterise the population. For some of the patients the most recent follow-up fell outside the 2-month range. DAS28–CRP was thus available in only 526 patients and the HAQ in 626 patients. The demographic and disease-related data relating to the screened population are set out in table 1.

Table 1

Demographic and disease characteristics of the included population

Among the screened patients, 349 (42.0%) were already diagnosed with hypertension, 152 (19.1%) with ischaemic CVD and 74 (9.0%) with DM.

The spread of the traditional risk factors for ischaemic CVD is reported in table 2 for all 836 patients.

Table 2

The spread of cardiovascular risk factors for all the patients with number and percentage of the patients with observations or median and IQR range

Out of the 748 patients without previously diagnosed DM, 95 (14.3%) had an impaired fasting glucose (≥6.0 mmol/L), which means that DM cannot be excluded. A fasting glucose of 7.0 or greater indicates that the patient probably has undiagnosed DM. A total of 15 patients (2.0%) had a fasting glucose of 7.0 or greater.

Out of the 836 screened patients, 644 patients (77%) were not previously diagnosed with DM or CVD. The number of patients exceeding the recommended levels for each risk factor is shown in table 3.

Table 3

The number of patients exceeding the recommended levels reported for patients with no known DM or CVD and for the subgroups of patients with known CVD or DM displayed separately

Thirty-four patients reported that they had both CVD and DM. The recommended level for LDL cholesterol is 1.8 mmol/L or less for this group14 and 25 (73.5%) of these patients did not meet that recommendation. Among the 349 patients with known hypertension who already received antihypertensive medication, only 189 (54.2%) had a systolic blood pressure below 140 mm  Hg.

The SCORE system is not recommended for patients with known CVD and or DM as the SCORE chart will underestimate their risk.17 Due to a lack of blood test results in some of the 644 patients without known DM and CVD, we only managed to obtain a risk SCORE on 605 patients. In 170 (28.1%) of these patients the multiplication factor 1.5 was applied.

Based on the European recommendations, a SCORE less than 5% is considered to be low to moderate risk, 5–10% is high risk and 10% or greater is very high risk for cardiovascular death within 10 years.14 The risk SCORE are reported in table 4. When Denmark was considered to be a high-risk country, 20.2% of the patients without previously diagnosed CVD or DM had a high or very high risk (≥5%) for cardiovascular death within 10 years. Due to a reduced number of cardiovascular deaths, Denmark is now considered to be a low-risk area according to new recommendations from the European and Danish Societies of Cardiology.14 ,26 The number of patients with a SCORE of 5% or greater thus decreases to 16.2%. The corresponding number for female patients is 11.4%, decreasing to 6.9% and for male patients 45.3%, decreasing to 42.6% when using the low-risk score charts.14

Table 4

High-risk modified SCORE based on Denmark considered being a high-risk area and the extra RA risk for the 644 patients without DM and CVD, the European low risk area SCORE reports the risk SCORE in the period since Denmark has been considered to be a low-risk area (since May 2012)


By implementing systematic screening for cardiovascular risk factors in nursing consultations, the patient, the outpatient department and the patient's GP attained an overview of the patient's individual risk profile. This arrangement also allowed us to explore the patient's motivation for lifestyle changes and offer relevant health promotional training relating to the patient's everyday life, and offer written information (brochures) and support to initiate desired lifestyle changes in primary care.

Initiation or adjustment of lipid-lowering or anti-hypertensive medication or follow-up on lifestyle issues in general would require extra follow-up visits, and we considered that the work involved would lie outside the rheumatologists’ core competences. We therefore chose to refer these patients to their GPs. The screened patients seem representative of the more than 16 000 Danish RA patients registered in the DANBIO registry (73% women and 73% RF positive).27 The patients seen at King Christian X's Hospital for Rheumatic Disease represent more than 90% of known patients with RA in the uptake area for the hospital.28

We found that 14.3% of the patients without known DM had an impaired fasting glucose (≥6.0 mmol/L), meaning that DM cannot be excluded.29 Two per cent had a fasting glucose of 7 mmol/L or greater, which is considered in Denmark to be the threshold for diagnosing DM.29 The percentages with elevated fasting glucose above 6 and 7 mM/L were even higher in the subgroup with known CVD (27.2% and 10.3%, respectively). In a Danish study from 2003, the prevalence of impaired fasting glucose varied between 4.7% and 17.8%, depending on age and gender.30 The prevalence of DM is increasing and increases with increasing age, BMI, lack of physical activity and male gender.30

CVD was already known in 19.1% of the patients and 42% were diagnosed with hypertension, compared to 9.3% with CVD and 32% with hypertension in a European sample.31 Although 42% of our sample was already treated with anti-hypertensive drugs, only 54.2% of these patients had a systolic blood pressure below 140 mm  Hg at the time of the consultation. The prevalence of a well-treated systolic blood pressure is a little higher in the Danish general population (63.1%).32 Unfortunately, 63.8% in the group who were already known to have CVD had elevated high blood pressure and, among patients with DM, 73.6% had blood pressure above the recommended level of 130 mm  Hg.

Inflammation seems to affect the cholesterol level in a paradoxical way, such as a decline in LDL-cholesterol when the patient's CRP level is increased.33 The median value and IQR for the CRP and DAS28–CRP (table 1) are within the normal range and thus the lipid paradox may not be applicable for our population. Although quite a few were probably already on lipid-lowering treatment, 55.4% of the patients without known DM or CVD still had a LDL-cholesterol above 5.0 mmol/L. The situation was even more exacerbated in the group of patients with known CVD (84.2%) or DM (80.9%). There seems to be a large gender difference in the percentages with low HDL-cholesterol levels (ratio 3 : 1 for men/women), whereas this does not seem to the case in the share with high waist circumference; this concurs with the results from a US study.34

In 2010, 20.9% of the general Danish population were smokers and the proportion was 22.2% for residents in the region of southern Denmark.35 Among the screened patients, the number was 23%, decreasing to 17.1% if the patient had known CVD and 14.9% in patients with DM, indicating that smoking habits had changed in some patients after diagnosis. In the general population in Denmark 46.7% are overweight (BMI >25) and 13% are obese (BMI >30), and in the region of southern Denmark the numbers are 49.3% and 14%.35 The share of overweight is about one third higher (63.8%) in the screened patients and the number of obese is doubled in persons with RA with or without CVD (27.6/25.4%) compared to the general population. For people with diabetes, the problem is even greater (74.3% overweight and 39.2% obese), reflecting the cause for the increasing number of DM type II patients currently.14 Unfortunately, there is a positive linear association of BMI and all-cause mortality.14 ,36 The visceral adipose tissue in abdominal fat promotes intracellular inflammatory pathophysiological processes.36 Furthermore, the risk of hypertension is up to five times higher in obese individuals than in those with normal weight, and the risk of dyslipidaemia develops progressively with increasing BMI.36

A low alcohol intake may have a preventive effect on the development of CVD, whereas heavy drinking seems to increase the risk of CVD.37 ,38 Only 3.4% of the female and 13.7% of the male patients reported alcohol intake above the nationally recommended limits of 7/14 units per week, compared to 24.3% in the Danish general population above the age of 15 years and 20.8% in the region of southern Denmark.35 The main reason for this difference is probably due to the high percentage of patients treated with disease-modifying antirheumatic drugs, in which the number one choice is methotrexate, which requires a need for alcohol restriction.23

When the high-risk country charts and RA-modified risk were used, a fifth (20.2%) of the patients had an elevated risk of cardiovascular death. Using the SCORE charts for low-risk countries, this number is reduced to 16.2%. The SCORE may underestimate the absolute risk of cardiovascular death in 10 years, because increased disease activity, genetic dispositions to CVD, obesity and lack of exercise will further affect the patient's risk. The risk of cardiovascular events is probably increased even before diagnosis.39 ,40 It is very important that the patient's disease activity is treated to target at the same time as we are trying to reduce the patient's risk through the impact from the other risk factors.41 In our population, there were still 22.8% of patients with a DAS28–CRP above 3.2, indicating room for improvement.

In young people the SCORE will be low, regardless of smoking habits, cholesterol and blood pressure levels and thus the chart may underestimate their risk.17 In the new European guidelines for prevention of CVD,14 it is recommended that young people with a low risk should be scored by a relative risk chart. Furthermore, the SCORE chart only includes age groups up to 65–70 years,17 and thus will probably underestimate the risk for older patients.

One of the strengths of our study is the large number of patients and the systematic documentation in a national registry. Furthermore, most of the hospital population had been invited for a cardiovascular risk assessment during the first 15 months.

The study also had some limitations. Unfortunately, we are not able to report the exact number of patients who declined to participate and compare them to the group who participated to assess potential bias. We did not verify the patients’ self-reported version of whether they had extra-articular manifestations of their RA and comorbidities in registry data or in the patients’ clinical journals. This may have caused an underestimation of the modified risk scores. Also, we did not include information on whether patients had a family history of CVD, if patients were undergoing lipid-lowering treatment or whether they had severe kidney disease.

The results from this study can help other hospitals plan the resources needed for a systematic approach to screening. As we have reported the SCORE for both high and low-risk countries, other European countries can compare their risk SCORES to the ones reported in this study.

Our results indicate gender differences in lipid status and there are substantial gender differences in the distribution of the risk SCORE. The other risk factors should be further explored for age and gender differences. Future studies need to explore the patients’ experiences of screening consultations and reasons to decline participation, and whether the SCORE system provides a realistic estimation of the patients’ actual risk of cardiovascular death. This study provides a solid background for a prospective follow-up study to determine whether the patients actually visit their GP as recommended and whether changes in risk and development of CVD occur over time.


Systematic screening revealed several risk factors that required medical follow-up or support to initiate lifestyle changes in order to reduce patients’ risk of CVD and cardiovascular death. Cardiovascular risk management in patients with already known DM or CVD needs to be improved. When using the charts for high-risk countries, more than 20% of our patients have an increased risk of cardiovascular death in 10 years. When using the charts for low-risk countries, the number decreases to 16%.


The authors would like to acknowledge the multidisciplinary group who implemented the systematic screening (senior consultants Lis Smedegaard Andersen and Johnny Raun, head of the secretariat Anette Christensen, head of the department of clinical chemistry Charlotte Drachmann and the outpatient nurses Pia Rhode Rasmussen and Kirsten Nørret Hansen). They would like to thank Niels Steen Krogh from Zitelab and the DANBIO registry for cooperation in development of the CVR theme as part of a yearly visit. They also wish to thank Lorna Campbell for assistance in language editing.


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  • Handling editor Tore K Kvien

  • Contributors JP: Study design, data acquisition, data analysis, manuscript drafting. JC: Study design, data acquisition and critical comments to manuscript drafting. KHP: Study design and critical comments to manuscript drafting.

  • Competing interests None.

  • Ethics approval As this was an observational study in which screening consultations were implemented as an integral part of clinical practice at the hospital, ethical approval was not obtained and the patients were not asked for written consent to participate. The patients could decline to participate at any time without influencing their follow-up at the hospital in general. We did not invite patients considered have dementia or those over 85 years of age, as we considered it unethical to discuss lifestyle with this group of patients.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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