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Anti-TNF therapy in women with rheumatoid arthritis with a history of carcinoma in situ of the cervix
  1. Louise Kate Mercer,
  2. Audrey Sze Lin Low,
  3. James B Galloway,
  4. Kath D Watson,
  5. Mark Lunt,
  6. Deborah P M Symmons,
  7. Kimme L Hyrich on behalf of the BSRBR Control Centre Consortium
  1. Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
  1. Correspondence to Dr Kimme Hyrich, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT, UK; Kimme.hyrich{at}manchester.ac.uk

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While many studies have investigated the risk of cancer following exposure to tumour necrosis factor (TNF) inhibitors,1–3 data are scarce with respect to people with cancer prior to treatment.2 ,4 To our knowledge, no studies have looked at cancer risk following exposure to anti-TNF in patients with a history of premalignant conditions, such as cervical dysplasia and Barrett's oesophagus. Guidelines from the British Society for Rheumatology (BSR) advise caution when using anti-TNF in subjects with premalignant conditions.5 Given the uncertainties regarding the use of anti-TNF in people with premalignant conditions, we investigated the outcome of women with rheumatoid arthritis (RA) with a previous history of carcinoma in situ (CIS) of the cervix registered with the BSR Biologics Register.6

The BSR Biologics Register, established in 2001, is following two cohorts of patients: one cohort of patients with RA …

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