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AB1474-HPR Effect of vitamin E on immunity and inflammation in adults with active rheumatoid arthritis (RA)
  1. N. Aryaeian1,
  2. F. Shahram2,
  3. M. Djalali1,3
  1. 1Nutrition and Biochemistry, Tehran University of Medical Sciences
  2. 2Rheumatology, Rheumatology Research Center, Shariati Hospital, Tehran University Of Medical Sciences
  3. 3Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic Of

Abstract

Background Little information on the effects of Vitamin E on inflammation and immune function in humans is available so we decided to investigate the effect of Vitamin E on this autoimmune disease, as our knowledge for the first time.

Objectives This study investigated the effects of Vitamin E on the inflammatory mediators and Immunity factors in adults with active RA

Methods In a randomized, double-blind, placebo controlled clinical trial 43 RA patients were randomly divided into 2 groups, each group receiving one of the following daily supplement for 3 months; Group E: 400 mg Vitamin E, Group P: placebo. Cytokines, Citrolinated Antibody (CCP-A)were measured by Elisa method, Vitamin E measured by HPLC.

Results After study there were no significant differences between groups in cytokines IL2, IL4, TNFα, IL1β, Il2/IL4, CCP-A, WBC and Neutrophils, Lymphocyte, Monocytes, Eeosinophils numbers.TNFα decreased in 2 groups nonsignificantly, but its reduction was more in group E. IL1β increased in both groups P and E (P=0.004, P=0.041 respectively). IL4 decreased in groups E and P (P=0.07, P=0.068 respectively). ESR, CRP, DAS 28 and GPA decreased in group E (P≤0.05).

Conclusions Vitamin E probably can be useful in RA patients.

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Disclosure of Interest None Declared

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