Background Little information on the effects of Vitamin E on inflammation and immune function in humans is available so we decided to investigate the effect of Vitamin E on this autoimmune disease, as our knowledge for the first time.
Objectives This study investigated the effects of Vitamin E on the inflammatory mediators and Immunity factors in adults with active RA
Methods In a randomized, double-blind, placebo controlled clinical trial 43 RA patients were randomly divided into 2 groups, each group receiving one of the following daily supplement for 3 months; Group E: 400 mg Vitamin E, Group P: placebo. Cytokines, Citrolinated Antibody (CCP-A)were measured by Elisa method, Vitamin E measured by HPLC.
Results After study there were no significant differences between groups in cytokines IL2, IL4, TNFα, IL1β, Il2/IL4, CCP-A, WBC and Neutrophils, Lymphocyte, Monocytes, Eeosinophils numbers.TNFα decreased in 2 groups nonsignificantly, but its reduction was more in group E. IL1β increased in both groups P and E (P=0.004, P=0.041 respectively). IL4 decreased in groups E and P (P=0.07, P=0.068 respectively). ESR, CRP, DAS 28 and GPA decreased in group E (P≤0.05).
Conclusions Vitamin E probably can be useful in RA patients.
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Disclosure of Interest None Declared