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AB1199 Anxiety is associated with antiribosomal p antibody in childhood-onset systemic lupus erythematosus
  1. H. Aldar1,
  2. A.T. Lapa1,
  3. B. Belini1,
  4. N.A. Sinicato1,
  5. M. Postal1,
  6. P. Fernandes1,
  7. L.T.L. Costallat1,
  8. R. Marini2,
  9. S. Appenzeller3
  1. 1State University of Campinas, Campinas, Brazil
  2. 2Pediatrics, State University of Campinas
  3. 3Medicine, State University of Campinas, Campinas, Brazil

Abstract

Objectives To investigate the prevalence of the anti-ribosomal P (anti-P) antibodies in childhood-onset systemic lupus erythematosus patients (cSLE) and to elucidate the association between anti-P and disease activity, laboratory and treatment features in cSLE patients

Methods We included consecutive SLE patients with disease onset before the age of 16 (cSLE), first-degree relatives and age and healthy age and sex matched controls. cSLE patients were assessed for disease activity [SLE Disease Activity Index (SLEDAI)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)] and current drug exposures. Mood disorders were determined through Becks Depression and Becks Anxiety Inventory (BDI and BAI). Anti-P was measured by enzyme-linked immunosorbent assay using commercial kits. Clinical/laboratorial manifestations, disease activity, cumulative damage and drugs undertaken were assessed at time of blood withdrawal

Results We included 50 cSLE patients (mean age 16.82±3.46), 35 first-degree relatives (mean age 38.73±3.89) and 20 health controls (mean age 18.3±4.97). Anti-P was present in 13 (26%) cSLE patients. No first-degree relatives or controls presented anti-P (p<0.01). The presence of anti-P was associated with anxiety on cSLE (p<0,002). No other clinical/laboratorial manifestations or treatment were associated with anti-P in cSLE.

Conclusions Anti-P is frequently observed in cSLE patients and was associated with anxiety in this cohort. Grants FAPESP: 2008/02917-0; 2009/13046-3

Disclosure of Interest H. Aldar Grant/Research support from: FAPESP 2009/13046-3, A. Lapa Grant/Research support from: FAPESP 2010/13639-1, B. Belini Grant/Research support from: FAPESP 2009/12343-4, N. Sinicato Grant/Research support from: FAPESP 2010/13637-9, M. Postal Grant/Research support from: FAPESP 2009/10744-1, P. Fernandes: None Declared, L. Costallat: None Declared, R. Marini: None Declared, S. Appenzeller Grant/Research support from: FAPESP 2008/02917-0; Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (300447/2009-4)

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