Background 25 (OH) D3 (vitamin D) has an important role in preserving immune homoeostasis. Several surveys of rheumatology populations found reduced levels of vitamin D and association between vitamin D deficiency and disease activity.
Objectives To assess whether low serum vitamin D concentrations are related to disease activity of children with systemic lupus erythematosus (SLE).
Methods We retrospectively evaluated medical records of children with SLE retrospectively. Disease activitywas calculatedwithSLE disease activity (SLEDAI) score on the day the serum samples were drawn. Serum vitamin D level was measured by high-performance liquid chromatography (HPLC) method.
Results The study included 13 children,9 females (84.6%), with a mean age of 14.45±3.79 years and mean follow-up period of 24.1±20.34 months. The average level of serum vitamin D level was 23.92±16.7 ng/ml and SLEDAI score was 6.53±5.91. 4 children, whohave significantly lower vitamin D levels (<10 ng/ml), have also high disease activity scores (all have hematologic and lung involvement, two of them also have active renal disease). A patient who presented with acute renal failure, had very low (4.9 ng/ml) vitamin D levels. A significant negative correlation was found between the serum concentrations of vitamin D and SLEDAI scores (pearson’s correlation coefficient r=-0.707, p=0.007)
Conclusions In a cohort of patients with SLE originating from Turkey, vitamin D serum concentrations were found to be inversely related to disease activity. Vitamin D levels of children with SLE should be evaluated regularly and vitamin D supplementation should be given if necessary.
Disclosure of Interest None Declared
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