Background Erythema nodosum (EN) is an inflammation of the fat cells under the skin (panniculitis) characterized by tender red nodules. EN is an immunologic response to a variety of different causes.
Objectives The aim of this study is to evaluate the epidemiology, etiology, clinical manifestations, course, and prognosis of EN obseved in internal medecine
Methods Over 13 years, patients with EN were included in a retrospective study. After a history and a physical examination, a clinical diagnosis was made according to well-established criteria. Statistical analysis was performed by SPSS 14
Results We have collected 81 cases. They were 11 males and 70 females. The mean age at presentation was 37.6 years (range: 14-77). 22% of patients had presented an anterior episode of EN. The nodules were situated at the legs (97.5%), the thighs (16%) and the upper limbs (24.5%). The EN was bilateral in 92.6% of cases. The EN was frequently associated with fever (62%), joint pain and inflammation (27%). In about 33% of cases, the cause of EN was unknown. Unless, it was a streptococcal infection (41%), tuberculosis (4%), medications (11%), Behçet’s disease (6%), sarcoidosis (5%). Evolution under treatment was favorable and nodules of EN regressed within four weeks averagely. A recurrence of EN had occurred in 18.5% of cases.
Conclusions EN is the most frequent clinico-pathological variant of the panniculitides, it may be associated with a wide variety of diseases requiring a minute etiological research.
Sang Won Yi and Al. Erythema Nodosum: Clinicopathologic Correlations and Their Use in Differential Diagnosis. Yonsei Med J. 2007 August 31; 48(4): 601–608.
Requena L, Sánchez Yus E. Erythema nodosum. Semin Cutan Med Surg. 2007 Jun;26(2):114-25.
Requena L, Yus ES. Erythema nodosum. Dermatol Clin. 2008 Oct;26(4):425-38, v.
Disclosure of Interest None Declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.