Background Immunoglobulin A (IgA) is responsible for protection against infections of the respiratory and gastrointestinal tracts, and selective IgA deficiency (SIgAD) is the most common humoral immunodeficiency. It is speculated that its occurrence may predispose to the development of systemic lupus erythematosus (SLE).
Objectives To study the prevalence of SIgAD in patients with juvenile SLE (JSLE) in the Adolescent Rheumatology Clinic from the Hospital Universitário Clementino Fraga Filho – Universidade Federal do Rio de Janeiro, and compare, between the groups of patients with and without SIgAD, the age and the clinical manifestations at the diagnosis of JSLE; the index of disease activity at the time of analysis of levels of IgA; and family history of rheumatic diseases, autoimmune and/or congenital immunodeficiencies.
Methods We carried out a review of medical records of 63 patients diagnosed with JSLE according to the criteria of the American College of Rheumatology (ACR). Plasma levels of IgA in these patients were measured by nephelometry and were considered low when less than 70mg/dL. The demographic data, the clinical and laboratory profiles and family history were obtained by review of medical records.
Results The SIgAD was detected in 3 of 63 patients (4.8%). The clinical and laboratory profiles of the group with SIgAD was not significantly different from the group without SIgAD, not being observed a higher incidence of infections in this group of patients.
Conclusions It was noted a higher prevalence of SIgAD in patients with JSLE compared to the general population, but no significant clinical or laboratorial difference was observed between the patients with and without SIgAD.
JT Cassidy, RK Kitson & CL Selby. Selective IgA deficiency in children and adults with systemic lupus erythematosus. Lupus 2007; 16(8):647-650.
Disclosure of Interest None Declared
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