Background Fibromyalgia is a chronic disorder of uncertain etiology characterized by widespread pain and reduced threshold to pressure and other stimuli. Scientific evidences show a relationship between fibromyalgia and obesity. Insulin resistance, a key feature of obesity and metabolic syndrome (MS), is a now well-recognized cardiovascular risk factor.
Objectives Objective of the study was to evaluate insulin resistance in fibromyalgia patients compared with age- and sex- matched healthy women.
Methods For the present study 53 consecutive fibromyalgia female patients referred to the Internal Medicine Unit, University of Catanzaro (Italy) for chronic widespread pain were recruited. Fibromyalgia was diagnosed by a single specialist according to 1990 American College of Rheumatology (ACR) Criteria . For comparison, 50 healthy age- matched female subjects were used.
Body mass index (BMI), blood insulin and glucose were measured after overnight fasting. HOMA-IR, a surrogate measure of insulin resistance, was calculated as previously described by Matthews et al. 
Results Mean age was 58.3±6.9 for patients and 56.6±7.4 for controls (p>0.05). Patient’s BMI and HOMA-IR, an indirect measure of insulin resistance, were significantly higher compared to healthy age- matched controls (p<0.01 and p<0.05 respectively).
Conclusions Fibromyalgia patients have a higher degree of insulin resistance compared to healthy age-matched controls.
Wolfe, F., et al., The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum, 1990; 33(2): p. 160-72.
D.R. Matthews, J.P.Hosker. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 1985;28: 412-9
Disclosure of Interest None Declared
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