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AB1046 Combination of digital X-ray radiogrammetry and frax® in evaluation of structural-functional state of bone in postmenopausal women
  1. V. Povoroznyuk,
  2. N. Grygorieva,
  3. V. Povorozniuk
  1. Institute of Gerontology Ams Ukraine, Kyiv, Ukraine

Abstract

Aim The aim of the study was to estimate the informative value of digital X-ray radiogrammetry and its combination with FRAX® in evaluation of structural-functional state of bone in Ukrainaian postmenopausal women.

Methods 247 postmenopausal women aged 45-87 years were examined, average age 65±0.6 years, duration of postmenopausal period 16±1.6 years.

Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometer (DXA) and digital X-ray radiogrammetry (DXR) of the II-IV metacarpal bones. The ten years probability of major osteoporotic fracture calculated with FRAX®.

Results There is difference in distribution of bone indexes in depending of used methods. Among women which had osteoporosis of femoral neck by DXA, 73% had osteoporosis, 24% - osteopenia, 3% - norma data by DXR. Sensitivity of DXR indexes ranging was from moderate to high, but specificity was low (with femoral neck – 73% and 38%, total hip – 78% and 22%, lumbar spine – 56% and 18%, total body – 68% and 24% accordingly). Such sensitivity and specificity increased when combining DXR with the ten years probability of major osteoporotic fracture without BMD (FRAX®) (with femoral neck – 82% and 75%, total hip – 89% and 72%, lumbar spine – 64% and 58%, total body – 79% and 69% accordingly).

Conclusions DXR of is informative method in evaluation of structural-functional state of bone in postmenopausal women. Sensitivity and specificity increased when combining DXR with FRAX® from 56% and 18% up to 89% and 75% accordingly.

Disclosure of Interest None Declared.

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