Aim The aim of the study was to estimate the informative value of digital X-ray radiogrammetry and its combination with FRAX® in evaluation of structural-functional state of bone in Ukrainaian postmenopausal women.
Methods 247 postmenopausal women aged 45-87 years were examined, average age 65±0.6 years, duration of postmenopausal period 16±1.6 years.
Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometer (DXA) and digital X-ray radiogrammetry (DXR) of the II-IV metacarpal bones. The ten years probability of major osteoporotic fracture calculated with FRAX®.
Results There is difference in distribution of bone indexes in depending of used methods. Among women which had osteoporosis of femoral neck by DXA, 73% had osteoporosis, 24% - osteopenia, 3% - norma data by DXR. Sensitivity of DXR indexes ranging was from moderate to high, but specificity was low (with femoral neck – 73% and 38%, total hip – 78% and 22%, lumbar spine – 56% and 18%, total body – 68% and 24% accordingly). Such sensitivity and specificity increased when combining DXR with the ten years probability of major osteoporotic fracture without BMD (FRAX®) (with femoral neck – 82% and 75%, total hip – 89% and 72%, lumbar spine – 64% and 58%, total body – 79% and 69% accordingly).
Conclusions DXR of is informative method in evaluation of structural-functional state of bone in postmenopausal women. Sensitivity and specificity increased when combining DXR with FRAX® from 56% and 18% up to 89% and 75% accordingly.
Disclosure of Interest None Declared.