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AB1057 Osteoporosis in calcium pyrophosphate deposition disease
  1. F. Kudaeva,
  2. S. Vladimirov,
  3. V. Barskova
  1. Metabolic Disorders, Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Objectives To study the frequency of osteoporosis (OP) in patients with calcium pyrophosphate deposition disease (CPPD).

Methods 85 pts with crystal-proven diagnosis of CPPD and chondrocalcinosis phenomena, confirmed either by conventional radiography (Rg) or by ultrasonography (US) of the joints, were enrolled. Following investigations were performed in pts: Rg and US of the knees and wrists, dual x ray absorptiometry (DXA) of the forearm, femoral neck and lumbar spine. Blood analysis included detection of hsCRP, parathyroid hormone, calcium, magnesium, phosphorus levels, and detection of 24-urinary excretion of calcium and phosphorus. Based on the results of bone mineral density (BMD) the pts were diagnosed with OP (N score lower -2,5 SD), osteopenia (N score between -1 and -2,5 SD), revealed at least in one area. Normal BMD was defined as a T score above -1 SD. According to the level of BMD pts were divided into 3 groups: 1gr - pts with normal BMD (n=34), 2 gr – pts with osteopenia (n=38), 3 gr – pts with OP (n=13).

Results There was no difference in age between pts in three groups (56,26±12,16 ys in the 1st, 58,33±9,03 ys in the 2nd and 66,15±14,44 ys in the 3d group, d=0,33). There was prevalence of male in the 1st group (62%), in the 2nd group the number of male and female was the same, in the 3d group number of female were higher (62%) (d=0,06). Contributed to the development of BMD changes in pts with CPPD, risk factors appeared to be diuretics intake, hyperparathyroidism (HPT) and fractures. Table 1 shows the frequency of risk factors in pts with CPPD.

Table 1. Risk factors of BMD changes in patients with CPPD

Data shows high frequency of HPT and fractures in pts in the 2nd and 3d group. No difference was recorded in calcium, phosphorus and magnesium serum levels between pts in 3 groups. Level of 24-hour urinary phosphorus excretion appeared to be lower in pts in the 3d group (27,2±14,47 mcmol/24h, 26,37±11,57 mcmol/24h and 17,38±12,41 mcmol/24h in pts of 1st, 2nd and 3d group, correspondingly, d<0,05).

Conclusions Taking diuretics was registered more often in patients with CPPD and OP detected at least in one area. HPT as a risk factor of CPPD occurred in patients with both osteopenia and OP. Presence of bone fractures occurred more frequently in patients with OP.

Disclosure of Interest None Declared

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