Objectives To study the prevalence of radiological osteoarthritis and chondrocalcinosis (CC) of hand in patients with Calcium pyrophosphate deposition (CPPD) and its correlation with clinical manifestations.
Methods 60 pts with CPPD were included in the study. Arthritis of different localizations was observed in all pts. Hand involvement occurred in 35 (58,3%) pts. Diagnosis CPPD was confirmed by the identification of CPP crystals in synovial fluid of the knees and radiological and/or ultrasound signs of chondrocalcinosis. All pts underwent bilateral posteroanterior hand radiographs. Two radiological signs were estimated: CC and radiological hand osteoarthritis at Kellgren-Lawrence grade (KLG)≥2.
Results Mean age of pts was 58,8±11,4years, 60%>men and 40% - women. Radiological typical CC was identified in 53,3% pts. Bilateral CC was defined in 25% pts.
Results of X-ray for hand-joint groups are submitted in the table 1.
Radiological OA (KLG≥2) have been observed more frequently in the distal joints of the hands, than in the wrist (d=0,025), while the CC prevailed in the wrist (d=0,0067). Radiological HOA and CC did not correlate with hand arthritis on the moment of investigation. Correlation between radiological grades HOA and age of patients has been taped (d <0,05). The X-ray pattern testifies to more expressed changes in the DIP of the right hand, than the left (p=0,0422).
Conclusions More than half pts with CPPD developed arthritis of the hand joints (58%) with most common localization in the wrist. Radiological OA and CC were common signs in60 ptswith CPPD, either. Radiological HOA have been more expressed in the distal joints of the hands and CC in the wrist. Nevertheless, there were no statistical correlation between radiological grade HOA, CC and development of hand arthritis in pts with CPPD.
Disclosure of Interest None Declared